DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Seung Ju | ko |
dc.contributor.author | Park, Hoyong | ko |
dc.contributor.author | Kim, Min-Gyu | ko |
dc.contributor.author | Zhang, Seungjae | ko |
dc.contributor.author | Park, Seung Eun | ko |
dc.contributor.author | Kim, Seyun | ko |
dc.contributor.author | Chung, ChiHye | ko |
dc.date.accessioned | 2020-06-10T05:20:06Z | - |
dc.date.available | 2020-06-10T05:20:06Z | - |
dc.date.created | 2020-06-08 | - |
dc.date.created | 2020-06-08 | - |
dc.date.created | 2020-06-08 | - |
dc.date.issued | 2020-04 | - |
dc.identifier.citation | ISCIENCE, v.23, no.4 | - |
dc.identifier.issn | 2589-0042 | - |
dc.identifier.uri | http://hdl.handle.net/10203/274589 | - |
dc.description.abstract | The coordination of synaptic vesicle exocytosis and endocytosis supports neurotransmitter release from presynaptic terminals. Although inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (5-IP7), are versatile signaling metabolites in many biological events, physiological actions of 5-IP7 on synaptic membrane vesicle trafficking remain unclear. Here, we investigated the role of 5-IP7 in synaptic transmission in hippocampal brain slices from inositol hexakisphosphate kinase 1 (Ip6k1)-knockout mice. We found that presynaptic release probability was significantly increased in Ip6k1-knockout neurons, implying enhanced activity-dependent synaptic vesicle exocytosis. Expression of wild-type but not catalytically inactive IP6K1 in the Ip6k1-knockout hippocampus restored the altered presynaptic release probability. Moreover, Ip6k1-knockout neurons were insensitive to folimycin, a vacuolar ATPase inhibitor, and dynasore, a dynamin inhibitor, suggesting marked impairment in synaptic endocytosis during exocytosis. Our findings collectively establish that IP6K1 and its product, 5-IP7, act as key physiological determinants for inhibition of pre-synaptic vesicle exocytosis and stimulation of endocytosis at central synapses. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses | - |
dc.type | Article | - |
dc.identifier.wosid | 000528359400032 | - |
dc.identifier.scopusid | 2-s2.0-85082758162 | - |
dc.type.rims | ART | - |
dc.citation.volume | 23 | - |
dc.citation.issue | 4 | - |
dc.citation.publicationname | ISCIENCE | - |
dc.identifier.doi | 10.1016/j.isci.2020.101000 | - |
dc.contributor.localauthor | Kim, Seyun | - |
dc.contributor.nonIdAuthor | Park, Hoyong | - |
dc.contributor.nonIdAuthor | Zhang, Seungjae | - |
dc.contributor.nonIdAuthor | Chung, ChiHye | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | SYNAPTIC VESICLE | - |
dc.subject.keywordPlus | HEXAKISPHOSPHATE KINASE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DYNAMIN | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | TRANSMISSION | - |
dc.subject.keywordPlus | ENDOCYTOSIS | - |
dc.subject.keywordPlus | INHIBITION | - |
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