#### Double-High-Pass-Filter-Based Electrical-Recording Front-Ends and Fluorescence-Recording Front-Ends for Monitoring Multimodal Neural Activity

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This brief presents a multimodal neural activity monitoring system consisting of a double-high-pass-filter-based electrical-recording front-end and a fluorescence-recording front-end. The proposed electrical-recording circuit based on double high-pass filters is implemented by placing a narrow-band buffer in the feedback path of the low-noise and programmable-gain amplifiers so that low-frequency artifacts can be sufficiently suppressed during the electrical and fluorescence recording. The implemented system successfully measures the electrical signals and calcium ions in vivo for studying heterogeneous cell populations. For electrical recording, the front-end consumes the power of 2 $\mu \text{W}$ /channel and achieves the input-referred noise of 2.9 $\mu \text{V}_{\mathrm{ rms}}$ . The high-pass cutoff frequency can be programmed from sub-1 Hz to about 300 Hz using the function of double high-pass filtering. For fluorescence recording, the front-end consumes the power of 10.8 $\mu \text{W}$ /block and occupies the area of 0.18 mm(2)/block.
Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Issue Date
2020-05
Language
English
Article Type
Article
Citation

IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS, v.67, no.5, pp.876 - 880

ISSN
1549-7747
DOI
10.1109/TCSII.2020.2980009
URI
http://hdl.handle.net/10203/274311
Appears in Collection
EE-Journal Papers(저널논문)
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