Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts

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High doses of chemotherapy agents can cause adverse effects. To address this issue, drug-loaded vesicles with minimum drug loss, guided by an external element for precise delivery, are desired. Combinational therapy of both a focused ultrasound-induced drug delivery method and membrane fusogenic liposomes (MFLs) as drug delivery vehicles can satisfy such premises. In this study, we confirmed that the use of a small quantity of docetaxel-loaded membrane fusogenic liposomes (DTX-MFL) with focused ultrasound can induce better antitumor response in a xenograft mouse model compared to conventional docetaxel monotherapy and DTX-MFL only.
Publisher
MDPI
Issue Date
2020-03
Language
English
Article Type
Article
Citation

MATERIALS, v.13, no.5

ISSN
1996-1944
DOI
10.3390/ma13051099
URI
http://hdl.handle.net/10203/274123
Appears in Collection
BiS-Journal Papers(저널논문)
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