DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Hojun | ko |
dc.contributor.author | Kim, Youngeun | ko |
dc.contributor.author | Mirzaaghasi, Amin | ko |
dc.contributor.author | Heo, Jaenyoung | ko |
dc.contributor.author | Kim, Yu Na | ko |
dc.contributor.author | Shin, Ju Hye | ko |
dc.contributor.author | Kim, Seonghun | ko |
dc.contributor.author | Kim, Nam Hee | ko |
dc.contributor.author | Cho, Eunae Sandra | ko |
dc.contributor.author | Yook, Jong In | ko |
dc.contributor.author | Yoo, Tae-Hyun | ko |
dc.contributor.author | Song, Eunjoo | ko |
dc.contributor.author | Kim, Pilhan | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Chung, Kyungsoo | ko |
dc.contributor.author | Choi, Kyungsun | ko |
dc.contributor.author | Choi, Chulhee | ko |
dc.date.accessioned | 2020-05-06T09:20:15Z | - |
dc.date.available | 2020-05-06T09:20:15Z | - |
dc.date.created | 2020-04-27 | - |
dc.date.created | 2020-04-27 | - |
dc.date.created | 2020-04-27 | - |
dc.date.issued | 2020-04 | - |
dc.identifier.citation | SCIENCE ADVANCES, v.6, no.15 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/10203/274113 | - |
dc.description.abstract | As extracellular vesicles that play an active role in intercellular communication by transferring cellular materials to recipient cells, exosomes offer great potential as a natural therapeutic drug delivery vehicle. The inflammatory responses in various disease models can be attenuated through introduction of super-repressor I kappa B (srI kappa B), which is the dominant active form of I kappa B alpha and can inhibit translocation of nuclear factor kappa B into the nucleus. An optogenetically engineered exosome system (EXPLOR) that we previously developed was implemented for loading a large amount of srI kappa B into exosomes. We showed that intraperitoneal injection of purified srI kappa B-loaded exosomes (Exo-srI kappa Bs) attenuates mortality and systemic inflammation in septic mouse models. In a biodistribution study, Exo-srI kappa Bs were observed mainly in the neutrophils, and in monocytes to a lesser extent, in the spleens and livers of mice. Moreover, we found that Exo-srlicB alleviates inflammatory responses in monocytic THP-1 cells and human umbilical vein endothelial cells. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Exosome-based delivery of super-repressor I kappa B alpha relieves sepsis-associated organ damage and mortality | - |
dc.type | Article | - |
dc.identifier.wosid | 000525751400037 | - |
dc.identifier.scopusid | 2-s2.0-85083213850 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 15 | - |
dc.citation.publicationname | SCIENCE ADVANCES | - |
dc.identifier.doi | 10.1126/sciadv.aaz6980 | - |
dc.contributor.localauthor | Kim, Pilhan | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.localauthor | Choi, Chulhee | - |
dc.contributor.nonIdAuthor | Kim, Youngeun | - |
dc.contributor.nonIdAuthor | Heo, Jaenyoung | - |
dc.contributor.nonIdAuthor | Kim, Yu Na | - |
dc.contributor.nonIdAuthor | Shin, Ju Hye | - |
dc.contributor.nonIdAuthor | Kim, Seonghun | - |
dc.contributor.nonIdAuthor | Kim, Nam Hee | - |
dc.contributor.nonIdAuthor | Cho, Eunae Sandra | - |
dc.contributor.nonIdAuthor | Yook, Jong In | - |
dc.contributor.nonIdAuthor | Yoo, Tae-Hyun | - |
dc.contributor.nonIdAuthor | Song, Eunjoo | - |
dc.contributor.nonIdAuthor | Chung, Kyungsoo | - |
dc.contributor.nonIdAuthor | Choi, Kyungsun | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ENDOTOXIC-SHOCK | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | NEUTROPHILS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | SIRNA | - |
dc.subject.keywordPlus | IL-8 | - |
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