The combinatorial development of refractory high-entropy alloy AlxTayVz-Cr20Mo20Nb20Ti20Zr10 (AlxTayVz-Q) was carried out, and microstructural analysis was performed. The homogenized AlxTayVz-Q revealed a body-centered cubic structure with intermetallic phases. High-temperature oxidation analysis of AlxTayVz-Q for 1 h at 1000 degrees C using thermogravimetric analysis (TGA) revealed volatile oxidation of the alloy. Therefore, in an effort to improve the oxidation resistance of the alloy, the composition was modified to Al(10)CrMo(x)NbTiZr(1)0 and analyzed. The TGA analysis revealed enhanced oxidation resistance of Al10CrNbTiZr10 (Mo-0), and a weight gain of only 1 mg/cm(2) after oxidation for 1 h at 1000 degrees C in air, owing to the formation of the protective oxides of Al and Cr. The Mo-x samples were subjected to prolonged oxidation (for 50 h) at 1000 degrees C in air. After 50 h of oxidation, the Mo-0 sample showed a weight gain of similar to 24 mg/cm(2) and remained intact. The energy dispersive spectroscopy analysis of the oxide scale formed after 50 h of oxidation revealed CrNbO4, Al2O3, and AlTiO5, which account for the enhanced oxidation resistance of Mo-0 and forecasts its potential for high-temperature applications.