A common hub for sleep and motor control in the substantia nigra

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The arousal state of the brain covaries with the motor state of the animal. How these state changes are coordinated remains unclear. We discovered that sleep-wake brain states and motor behaviors are coregulated by shared neurons in the substantia nigra pars reticulata (SNr). Analysis of mouse home-cage behavior identified four states with different levels of brain arousal and motor activity: locomotion, nonlocomotor movement, quiet wakefulness, and sleep; transitions occurred not randomly but primarily between neighboring states. The glutamic acid decarboxylase 2 but not the parvalbumin subset of SNr gamma-aminobutyric acid (GABA)-releasing (GABAergic) neurons was preferentially active in states of low motor activity and arousal. Their activation or inactivation biased the direction of natural behavioral transitions and promoted or suppressed sleep, respectively. These GABAergic neurons integrate wide-ranging inputs and innervate multiple arousal-promoting and motor-control circuits through extensive collateral projections.
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Issue Date
2020-01
Language
English
Article Type
Article
Citation

SCIENCE, v.367, no.6476, pp.440 - +

ISSN
0036-8075
DOI
10.1126/science.aaz0956
URI
http://hdl.handle.net/10203/272423
Appears in Collection
BiS-Journal Papers(저널논문)
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