Deep tissue space-gated microscopy via acousto-optic interactions

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To extend the imaging depth of high-resolution optical microscopy, various gating operations—confocal, coherence, and polarization gating—have been devised to filter out the multiply scattered wave. However, the imaging depth is still limited by the multiply scattered wave that bypasses the existing gating operations. Here, we present a space gating method, whose mechanism is independent of the existing methods and yet effective enough to complement them. Specifically, we reconstruct an image only using the ballistic wave that is acousto-optically modulated at the object plane. The space gating suppresses the multiply scattered wave by 10–100 times in a highly scattering medium, and thus enables visualization of the skeletal muscle fibers in whole-body zebrafish at 30 days post fertilization. The space gating will be an important addition to optical-resolution microscopy for achieving the ultimate imaging depth set by the detection limit of ballistic wave.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2020-02
Language
English
Article Type
Article
Citation

NATURE COMMUNICATIONS, v.11, no.1, pp.710

ISSN
2041-1723
DOI
10.1038/s41467-020-14514-7
URI
http://hdl.handle.net/10203/272410
Appears in Collection
BiS-Journal Papers(저널논문)
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