PRMT1 Is Required for the Maintenance of Mature β-Cell Identity

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dc.contributor.authorKim, Hyunkiko
dc.contributor.authorYoon, Byoung-Hako
dc.contributor.authorOh, Chang-Myungko
dc.contributor.authorLee, Joonyubko
dc.contributor.authorLee, Kanghoonko
dc.contributor.authorSong, Heeinko
dc.contributor.authorKim, Eunhako
dc.contributor.authorYi, Kijongko
dc.contributor.authorKim, Mi-Youngko
dc.contributor.authorKim, Hyeongseokko
dc.contributor.authorKim, Yong Kyungko
dc.contributor.authorSeo, Eun-Hyeko
dc.contributor.authorHeo, Haejeongko
dc.contributor.authorKim, Hee-Jinko
dc.contributor.authorLee, Jungueeko
dc.contributor.authorSuh, Jae Myoungko
dc.contributor.authorKoo, Seung-Hoiko
dc.contributor.authorSeong, Je Kyungko
dc.contributor.authorKim, Seyunko
dc.contributor.authorJu, Young Seokko
dc.contributor.authorShong, Minhoko
dc.contributor.authorKim, Mirangko
dc.contributor.authorKim, Hailko
dc.date.accessioned2020-03-19T01:23:21Z-
dc.date.available2020-03-19T01:23:21Z-
dc.date.created2020-03-16-
dc.date.created2020-03-16-
dc.date.created2020-03-16-
dc.date.created2020-03-16-
dc.date.created2020-03-16-
dc.date.issued2020-03-
dc.identifier.citationDIABETES, v.69, no.3, pp.355 - 368-
dc.identifier.issn0012-1797-
dc.identifier.urihttp://hdl.handle.net/10203/272354-
dc.description.abstractLoss of functional beta-cell mass is an essential feature of type 2 diabetes, and maintaining mature beta-cell identity is important for preserving a functional beta-cell mass. However, it is unclear how beta-cells achieve and maintain their mature identity. Here we demonstrate a novel function of protein arginine methyltransferase 1 (PRMT1) in maintaining mature beta-cell identity. Prmt1 knockout in fetal and adult beta-cells induced diabetes, which was aggravated by high-fat diet-induced metabolic stress. Deletion of Prmt1 in adult beta-cells resulted in the immediate loss of histone H4 arginine 3 asymmetric dimethylation (H4R3me2a) and the subsequent loss of beta-cell identity. The expression levels of genes involved in mature beta-cell function and identity were robustly downregulated as soon as Prmt1 deletion was induced in adult beta-cells. Chromatin immunoprecipitation sequencing and assay for transposase-accessible chromatin sequencing analyses revealed that PRMT1-dependent H4R3me2a increases chromatin accessibility at the binding sites for CCCTC-binding factor (CTCF) and beta-cell transcription factors. In addition, PRMT1-dependent open chromatin regions may show an association with the risk of diabetes in humans. Together, our results indicate that PRMT1 plays an essential role in maintaining beta-cell identity by regulating chromatin accessibility.-
dc.languageEnglish-
dc.publisherAMER DIABETES ASSOC-
dc.titlePRMT1 Is Required for the Maintenance of Mature β-Cell Identity-
dc.typeArticle-
dc.identifier.wosid000515719900010-
dc.identifier.scopusid2-s2.0-85081142381-
dc.type.rimsART-
dc.citation.volume69-
dc.citation.issue3-
dc.citation.beginningpage355-
dc.citation.endingpage368-
dc.citation.publicationnameDIABETES-
dc.identifier.doi10.2337/db19-0685-
dc.contributor.localauthorSuh, Jae Myoung-
dc.contributor.localauthorKim, Seyun-
dc.contributor.localauthorJu, Young Seok-
dc.contributor.localauthorShong, Minho-
dc.contributor.localauthorKim, Hail-
dc.contributor.nonIdAuthorYoon, Byoung-Ha-
dc.contributor.nonIdAuthorOh, Chang-Myung-
dc.contributor.nonIdAuthorLee, Joonyub-
dc.contributor.nonIdAuthorSong, Heein-
dc.contributor.nonIdAuthorKim, Mi-Young-
dc.contributor.nonIdAuthorKim, Yong Kyung-
dc.contributor.nonIdAuthorSeo, Eun-Hye-
dc.contributor.nonIdAuthorHeo, Haejeong-
dc.contributor.nonIdAuthorKim, Hee-Jin-
dc.contributor.nonIdAuthorLee, Junguee-
dc.contributor.nonIdAuthorKoo, Seung-Hoi-
dc.contributor.nonIdAuthorSeong, Je Kyung-
dc.contributor.nonIdAuthorKim, Mirang-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusINSULIN-SECRETION-
dc.subject.keywordPlusARGININE METHYLTRANSFERASE-
dc.subject.keywordPlusTRANSCRIPTION FACTORS-
dc.subject.keywordPlusCHROMATIN STATE-
dc.subject.keywordPlusHISTONE H4-
dc.subject.keywordPlusMETHYLATION-
dc.subject.keywordPlusPDX1-
dc.subject.keywordPlusARCHITECTURE-
dc.subject.keywordPlusMATURATION-
dc.subject.keywordPlusDEDIFFERENTIATION-
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MSE-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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