Community structure changes in brain functional networks of mild cognitive impairment patients = 경도인지장애 환자의 뇌기능 네트워크 군집구조의 변화

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Mild Cognitive Impairment (MCI) is a neurological diagnosis given to people who have impaired cognitive abilities beyond the standard of their age, but that do not interfere significantly with their daily lives. Patients with MCI have a high risk to suffer from Alzheimer’s disease (AD) within a few years. Although AD is a degenerative disease which starts from a local lesion, its effects on cognitive abilities are immediate and global, because AD is generally accepted as a disconnection syndrome. Since human brain is organized into functionally segregated units as well as anatomically distinct parts, we investigated how topological organizations change in brain functional networks of MCI patients. In order to clarify this change, we adopted a community detection algorithm and modular structure analysis from the graph theory. As a result, we found overall community structure was less distinct and less segregated in MCI. Also, the structural stability was decreased in that the bond between brain regions in the same module was weakened. We suggest that this distortion and instability of community structures of functional networks are responsible for cognitive deficits of MCI patients and hope the module analysis might play a role in a diagnosis of MCI and the early stage of AD in addition to traditional clinical diagnosis and structural imaging.
Advisors
Jeong, Jae-Seungresearcher정재승researcher
Description
한국과학기술원 : 바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2010
Identifier
455159/325007  / 020083296
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2010.08, [ iv, 49 p. ]

Keywords

community structure; graph theory; brain functional network; mild cognitive dementia; modularity; 모듈값; 군집구조; 그래프 이론; 뇌기능 네트워크; 경도인지장애

URI
http://hdl.handle.net/10203/27202
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=455159&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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