Iron competition triggers antibiotic biosynthesis in Streptomyces coelicolor during coculture with Myxococcus xanthus

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 155
  • Download : 0
DC FieldValueLanguage
dc.contributor.author이남일ko
dc.contributor.author김우리ko
dc.contributor.author정진규ko
dc.contributor.author이용재ko
dc.contributor.author조수형ko
dc.contributor.author장경순ko
dc.contributor.author김선창ko
dc.contributor.authorBernhard, Palssonko
dc.contributor.author조병관ko
dc.date.accessioned2020-02-03T01:20:11Z-
dc.date.available2020-02-03T01:20:11Z-
dc.date.created2020-01-31-
dc.date.issued2019-01-15-
dc.identifier.citation2019 한국미생물, 생명공학회 동계심포지움 (KMB 2019)-
dc.identifier.urihttp://hdl.handle.net/10203/271986-
dc.description.abstractMicrobial coculture to mimic the ecological habitat has been suggested as an approach to elucidate the effect of microbial interaction on secondary metabolite biosynthesis of Streptomyces. However, because of chemical complexity during coculture, underlying mechanisms are largely unknown. Here, we found that iron competition triggered antibiotic biosynthesis in Streptomyces coelicolor during coculture with Myxococcus xanthus. During coculture, M. xanthus enhanced the production of a siderophore, myxochelin, leading M. xanthus to dominate iron scavenging and S. coelicolor to experience iron-restricted conditions. This chemical competition, but not physical contact, activated the actinorhodin biosynthetic gene cluster and the branched-chain amino acid degradation pathway which imply the potential to produce precursors, along with activation of a novel actinorhodin export system. Furthermore, we found that iron restriction increased the expression of 21 secondary metabolite biosynthetic gene clusters (smBGCs) in other Streptomyces species. These findings suggested that the availability for key ions stimulates specific smBGCs, which had the potential to enhance secondary metabolite biosynthesis in Streptomyces.-
dc.languageEnglish-
dc.publisher한국미생물생명공학회-
dc.titleIron competition triggers antibiotic biosynthesis in Streptomyces coelicolor during coculture with Myxococcus xanthus-
dc.typeConference-
dc.type.rimsCONF-
dc.citation.publicationname2019 한국미생물, 생명공학회 동계심포지움 (KMB 2019)-
dc.identifier.conferencecountryKO-
dc.identifier.conferencelocation용평리조트 블리스힐스테이 웰니스홀-
dc.identifier.doi10.1038/s41396-020-0594-6-
dc.contributor.localauthor조병관-
dc.contributor.nonIdAuthor김우리-
dc.contributor.nonIdAuthor정진규-
dc.contributor.nonIdAuthor이용재-
dc.contributor.nonIdAuthor조수형-
dc.contributor.nonIdAuthor장경순-
dc.contributor.nonIdAuthor김선창-
dc.contributor.nonIdAuthorBernhard, Palsson-
Appears in Collection
BS-Conference Papers(학술회의논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0