Spectrometric analysis using liquid metal mirrors in a microfluidic device = 미세유체소자 내 액체금속거울을 이용한 분광학적 분석

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This paper presents a new absorbance measurement device using multiple internal reflections and a new novel spectrometer for both of them using fluidic mirrors filled with liquid metal. Liquid metal mirrors reflect and gather light from LED with high reflectivity and small sample volume. Optical path length has been extended with various incident angles of 20$\deg$, 30$\deg$, 40$\deg$ and 50$\deg$. We demonstrated the enhancements of the sensitivity and limit of detection (LOD) compared to the air mirrors and linear channel. As incident angle lowers, optical path length extension becomes more effective without trade-offs of sensitivity and LOD. This device with incident angle of 50$\deg$ has a 84 nM of LOD and 3.62 x $10^{-4}$ of sensitivity for absorbance measurement of fluorecein diluted in deionized water. The spectrometer is suitable for direct spectral analysis in the sample channel plane using fluidic slit and mirror filled with liquid metal. Solutions of phenol red and trypan blue which are used widely for biomolecular detection are measured for spectrometric analysis. This platform can be simply adapted to the applications using the fiber optics integration. The measurements of phenol red and trypan blue result 212 nM, 154 nM of LOD and 1.09 x $10^{-3}$, 8.10 x $10^{-4}$ of sensitivity respectively.
Advisors
Park, Je-Kyunresearcher박제균researcher
Description
한국과학기술원 : 바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2010
Identifier
418988/325007  / 020083538
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2010.2, [ viii, 54 p. ]

Keywords

liquid metal mirror; spectrometer; lab on a chip; 랩칩; 액체금속거울; 분광분석기

URI
http://hdl.handle.net/10203/27191
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=418988&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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