Cell signaling dynamics analysis in leukemia with switching boolean networks = 스위칭부울네트워크를 이용한 백혈병 세포신호 동역학 해석

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To make model and analyze biological signaling network is a major challenge of Systems Biology. Here we suggest Switching Boolean Network using Threshold Boolean Network and we made Acute myeloid leukemia (AML) signaling network and analyzed this network to find component which make signaling network abnormal by being deregulated. Acute myeloid leukemia (AML) features the rapid growth of abnormal white blood cells that accumulate in the bone marrow and perturb the production of normal blood cells. We constructed AML singling network by combining the signaling pathways involved in myeloid differentiation or cell proliferation. We analyzed this singling network using Switching Boolean network. The result of this analysis showed similar result with previous studies. Some of the components which we found in this simulation were experimentally validated by other research. Some of them were new foundation.
Advisors
Lee, Do-Heonresearcher이도헌researcher
Description
한국과학기술원 : 바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2010
Identifier
418888/325007  / 020083588
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2010.2, [ iv, 34 p. ]

Keywords

AML; Signal transduction network; Boolean Networks; Acute Myeloid Leukemia; 급성 골수성 백혈병; 시스템생물학; 신호전달회로; 부울네트워크; System Biology

URI
http://hdl.handle.net/10203/27185
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=418888&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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