Cell signaling dynamics analysis in leukemia with switching boolean networks

Abstract

To make model and analyze biological signaling network is a major challenge of Systems Biology. Here we suggest Switching Boolean Network using Threshold Boolean Network and we made Acute myeloid leukemia (AML) signaling network and analyzed this network to find component which make signaling network abnormal by being deregulated. Acute myeloid leukemia (AML) features the rapid growth of abnormal white blood cells that accumulate in the bone marrow and perturb the production of normal blood cells. We constructed AML singling network by combining the signaling pathways involved in myeloid differentiation or cell proliferation. We analyzed this singling network using Switching Boolean network. The result of this analysis showed similar result with previous studies. Some of the components which we found in this simulation were experimentally validated by other research. Some of them were new foundation.