Human breast cancer classification using combined analysis of CNVs and gene expression = DNA 복제수 변이와 유전자 발현을 이용한 인간 유방암 분류에 관한 연구

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DNA copy number variant is a DNA segment in which copy-number differences have been found by comparison of reference genomes. DNA copy number variants have been studied for prognostic/diagnostic biomarkers, tumor classifications, tumor progression markers, and so on. However, there was no paper to classify tumors using combined analysis of DNA copy number variants and gene expression data based on pathway analysis. We introduced new features which have classification power from DNA copy number variants based on pathway analysis. Also, we confirmed that human breast cancer samples have specific DNA copy number pattern related with gene ER. From this result, we found that combined analysis of DNA copy number variants and gene expression profiles improved the accuracy of human breast cancer classification.
Advisors
Lee, Do-Heonresearcher이도헌researcher
Description
한국과학기술원 : 바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2009
Identifier
327258/325007  / 020074228
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2009. 8., [ vii, 32 p. ]

Keywords

DNA copy number variants; CNV; gene expression; cancer classification; DNA 복제수 변이; 유전자 발현; 암 분류; DNA copy number variants; CNV; gene expression; cancer classification; DNA 복제수 변이; 유전자 발현; 암 분류

URI
http://hdl.handle.net/10203/27177
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=327258&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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