Distinct effects of reward and navigation history on hippocampal forward and reverse replays

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dc.contributor.authorBhattarai, Baburamko
dc.contributor.authorLee, Jong Wonko
dc.contributor.authorJung, Min Whanko
dc.date.accessioned2020-01-21T07:20:05Z-
dc.date.available2020-01-21T07:20:05Z-
dc.date.created2020-01-21-
dc.date.created2020-01-21-
dc.date.created2020-01-21-
dc.date.issued2020-01-
dc.identifier.citationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.117, no.1, pp.689 - 697-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10203/271683-
dc.description.abstractTo better understand the functional roles of hippocampal forward and reverse replays, we trained rats in a spatial sequence memory task and examined how these replays are modulated by reward and navigation history. We found that reward enhances both forward and reverse replays during the awake state, but in different ways. Reward enhances the rate of reverse replays, but it increases the fidelity of forward replays for recently traveled as well as other alternative trajectories heading toward a rewarding location. This suggests roles for forward and reverse replays in reinforcing representations for all potential rewarding trajectories. We also found more faithful reactivation of upcoming than already rewarded trajectories in forward replays. This suggests a role for forward replays in preferentially reinforcing representations for high-value trajectories. We propose that hippocampal forward and reverse replays might contribute to constructing a map of potential navigation trajectories and their associated values (a "value map") via distinct mechanisms.-
dc.languageEnglish-
dc.publisherNATL ACAD SCIENCES-
dc.titleDistinct effects of reward and navigation history on hippocampal forward and reverse replays-
dc.typeArticle-
dc.identifier.wosid000506001200093-
dc.identifier.scopusid2-s2.0-85077499288-
dc.type.rimsART-
dc.citation.volume117-
dc.citation.issue1-
dc.citation.beginningpage689-
dc.citation.endingpage697-
dc.citation.publicationnamePROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.identifier.doi10.1073/pnas.1912533117-
dc.contributor.localauthorJung, Min Whan-
dc.contributor.nonIdAuthorLee, Jong Won-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorhippocampus-
dc.subject.keywordAuthorplace cell-
dc.subject.keywordAuthorvalue-
dc.subject.keywordAuthorsequence memory task-
dc.subject.keywordPlusPLACE-CELL SEQUENCES-
dc.subject.keywordPlusSHARP-WAVE RIPPLES-
dc.subject.keywordPlusEPISODIC MEMORY-
dc.subject.keywordPlusSPATIAL MEMORY-
dc.subject.keywordPlusAWAKE REPLAY-
dc.subject.keywordPlusREACTIVATION-
dc.subject.keywordPlusEXPERIENCE-
dc.subject.keywordPlusTIME-
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