Multiplex analysis of serum biomarkers of Alzheimer’s disease = 알츠하이머 질병의 복합적 혈청 분석

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The diagnosis of Alzheimer’s disease (AD) is currently based on clinical and neuropsychological examination. However, it is difficult to diagnose accurately early AD. Recently, Molecular biomarkers are becoming potential diagnosis method for early AD. Serum protein is being the center of attention for AD diagnostic biomarker. We collected serum samples and mini-mental state examination (MMSE) score data from 20 controls and 68 patients finally diagnosed with AD, and measured serum levels of Alzheimer related protein by Color-coded bead Technology. We found significant difference in several protein concentrations such as Ab42, glutamin synthetase, neurosin, s100-beta, transglutaminase2, ubiquitin, mutant ubiquitin. Moreover, our result also shows positive or negative correlation between MMSE scores and various biomarkers such as glutamin synthetase, S100-beta ubiquitin and mutant ubiquitin protein concentration. However, sensitivity and specificity is still poor. We propose here that multiple analysis of serum proteins increases test accuracy including sensitivity and specificity in the diagnosis of AD. That can be used to classify samples from Alzheimer’s and control subjects with close to 85% specificity and 82% sensitivity.
Advisors
Choi, Chul-Heeresearcher최철희researcher
Description
한국과학기술원 : 바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2009
Identifier
308638/325007  / 020064103
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2009.2, [ vi, 23 p. ]

Keywords

Alzheimer; Serum; biomarker; Multiple; 알츠하이머; 혈청; 바이오마커; 복합적; Alzheimer; Serum; biomarker; Multiple; 알츠하이머; 혈청; 바이오마커; 복합적

URI
http://hdl.handle.net/10203/27168
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=308638&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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