Predicting transcription factor binding sites with histone modification = 히스톤 변이를 이용한 전사조절 인자 결합지역 예측

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Histone modifications are associated with gene expression, influencing bind of transcription factor. Promoter and enhancer of human are characterized to combinatorial patterns of histone acetylation and methylation from ChIP-Seq data. However, because the data is only relative with gene, relation transcription factor of histone modification remains unclear. Here, we reported specific patterns of histone modification on transcriptional factor binding site (TFBS) from human CD4+ T cells. In result of comparing position of TFBS from TRANSFAC and position histone modification with gene expression, it represented a different histone pattern in TFBS between active and inactive gene expression. Specially, level of H3K4me3 at TFBS in active gene expression is a higher than silencing gene expression. This difference showed that we distinguished activity of TF binding in cell context. We also improved performance of TFBS prediction compared with sequence-based prediction. From this result, we developed new method for predicting TFBS to integrate sequence-based model with histone modification.
Advisors
Lee, Kwang-Hyungresearcher이광형researcher
Description
한국과학기술원 : 바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2009
Identifier
308632/325007  / 020073026
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2009.2, [ vii, 32 p. ]

Keywords

histone modification; transcription factor binding site; 히스톤변이; 전사조절인자 결합지역; histone modification; transcription factor binding site; 히스톤변이; 전사조절인자 결합지역

URI
http://hdl.handle.net/10203/27162
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=308632&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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