Development of transcranial magnetic stimulation for post-traumatic stress disorder therapy : a translational study based on animal model = 외상후 스트레스 장애 치료를 위한 경두개 자기자극 기법 개발 : 동물 모델에 기초한 중개 연구

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Post-traumatic stress disorder (PTSD) is a chronic detrimental anxiety disorder originated from exaggerate fear memory after a traumatic event. Impaired extinction of fear memory has been hypothesized for a tentative pathophysiology of PTSD based on dysfunction in the medial prefrontal cortex (mPFC) observed in functional neuroimaging studies of PTSD patients. Electrical stimulation of mPFC paired with extinction learning facilitated fear extinction in rats, but not unpaired one. Therefore, transcranial magnetic stimulation (TMS) paired with traumatic reminder was suggested as a potential treatment for PTSD. However, there was no clinical and preclinical study examining the effect of TMS paired with trauma-reminding cue presentation. We examined the effect of 10 Hz repetitive TMS paired with conditioned fear stimulus (CS) in fear memory extinction of rats, and one administered right after or before extinction learning. Only TMS paired with CS reduced fear response compared to sham control on the day of stimulation and the following day. No effect was observed for TMS given several minutes after or before fear extinction. Therefore, TMS paired with traumatic reminder can be a potential treatment for PTSD patients more effective than conventional TMS and exposure therapy. More generally, these results indicate that TMS paired with cognitive intervention such as fear extinction can have specific effect, possibly by transient modulation of neural activity underlying ongoing cognitive process.
Advisors
Jeong, Jae-seungresearcher정재승researcherLee, Do-heonresearcher이도헌researcher
Description
한국과학기술원 : 바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2008
Identifier
296161/325007  / 020063232
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2008.2, [ iv, 36 p. ]

Keywords

transcranial magnetic stimulation; post-traumatic stress disorder; fear extinction; therapeutic neuromodulation; translational neuroscience; 경두개 자기자극술; 외상후 스트레스 장애; 공포 소거; 치료용 뇌자극술; 중개 신경과학; transcranial magnetic stimulation; post-traumatic stress disorder; fear extinction; therapeutic neuromodulation; translational neuroscience; 경두개 자기자극술; 외상후 스트레스 장애; 공포 소거; 치료용 뇌자극술; 중개 신경과학

URI
http://hdl.handle.net/10203/27148
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=296161&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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