Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif

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The inhibitory effect of large tumor suppressor kinase (LATS1/2) on the activity of the oncoprotein yes-associated protein (YAP) is crucial to maintain tissue homeostasis. Proteomic studies have identified several new regulators of this process. Recently, citron kinase (CIT) was listed as a potential binding candidate of Hippo-related components, suggesting a new connection between CIT and the Hippo pathway. Aside from CIT’s role in cytokinesis, the molecular crosstalk between CIT and the Hippo pathway is largely unknown. Here, we demonstrate a role for CIT as a scaffold protein linking LATS2 and YAP. More importantly, CIT interacts with LATS2 to directly suppress LATS2 phosphorylation at the hydrophobic motif—targeted by MST1, leading to LATS2 inactivation and YAP activation. By studying their genetic interactions, we found that Sticky, the CIT homolog in Drosophila melanogaster, functions with Warts to control Drosophila eye development. Together, our study confirms citron kinase as a novel regulator of the Hippo pathway.
Publisher
OXFORD UNIV PRESS
Issue Date
2019-12
Language
English
Article Type
Article
Citation

JOURNAL OF MOLECULAR CELL BIOLOGY, v.11, no.11, pp.1006 - 1017

ISSN
1674-2788
DOI
10.1093/jmcb/mjz013
URI
http://hdl.handle.net/10203/271413
Appears in Collection
BS-Journal Papers(저널논문)
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