High-Sensitivity Parylene Microfluidic Chip Calorimeters for Measurements of Cellular Metabolic Heat

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Chip calorimeters are promising tools for quantitative analysis of cellular metabolic rate. The measurement of cellular metabolic heat can be an excellent indicator of its physiological state and the changes in response to external stimuli such as drugs. We have developed a highly sensitive microfluidic chip calorimeter capable of maintaining cellular activity and controlling the fluid flows of biochemical stimuli around the cells. Using the chip calorimeter, we demonstrated the measurements of cellular metabolic rate by monitoring the changes in power output of a few hundred cells responding to biochemical stimuli.
Publisher
Institute of Electrical and Electronics Engineers Inc.
Issue Date
2019-01-29
Language
English
Citation

32nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2019, pp.544 - 546

DOI
10.1109/MEMSYS.2019.8870722
URI
http://hdl.handle.net/10203/271298
Appears in Collection
NT-Conference Papers(학술회의논문)
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