Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth

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dc.contributor.authorKoo, Ja Hyunko
dc.contributor.authorPlouffe, Steven W.ko
dc.contributor.authorMeng, Zhipengko
dc.contributor.authorLee, Da-Hyeko
dc.contributor.authorYang, Diko
dc.contributor.authorLim, Dae-Sikko
dc.contributor.authorWang, Cun-Yuko
dc.contributor.authorGuan, Kun-Liangko
dc.date.accessioned2020-01-14T08:20:17Z-
dc.date.available2020-01-14T08:20:17Z-
dc.date.created2020-01-14-
dc.date.created2020-01-14-
dc.date.created2020-01-14-
dc.date.issued2020-01-
dc.identifier.citationGENES & DEVELOPMENT, v.34, no.1-2, pp.72 - 86-
dc.identifier.issn0890-9369-
dc.identifier.urihttp://hdl.handle.net/10203/271186-
dc.description.abstractYes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ) are key effectors of the Hippo pathway to control cell growth and organ size, of which dysregulation yields to tumorigenesis or hypertrophy. Upon activation, YAP/TAZ translocate into the nucleus and bind to TEAD transcription factors to promote transcriptional programs for proliferation or cell specification. Immediate early genes, represented by AP-1 complex, are rapidly induced and control later-phase transcriptional program to play key roles in tumorigenesis and organ maintenance. Here, we report that YAP/TAZ directly promote FOS transcription that in turn contributes to the biological function of YAP/TAZ. YAP/TAZ bind to the promoter region of FOS to stimulate its transcription. Deletion of YAP/TAZ blocks the induction of immediate early genes in response to mitogenic stimuli. FOS induction contributes to expression of YAP/TAZ downstream target genes. Genetic deletion or chemical inhibition of AP-1 suppresses growth of YAP-driven cancer cells, such as Lats1/2-deficient cancer cells as well as Ga-q/11 mutated uveal melanoma. Furthermore, AP-1 inhibition almost completely abrogates the hepatomegaly induced by YAP overexpression. Our findings reveal a feed-forward interplay between immediate early transcription of AP-1 and Hippo pathway function.-
dc.languageEnglish-
dc.publisherCOLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT-
dc.titleInduction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth-
dc.typeArticle-
dc.identifier.wosid000505172100007-
dc.identifier.scopusid2-s2.0-85077476047-
dc.type.rimsART-
dc.citation.volume34-
dc.citation.issue1-2-
dc.citation.beginningpage72-
dc.citation.endingpage86-
dc.citation.publicationnameGENES & DEVELOPMENT-
dc.identifier.doi10.1101/gad.331546.119-
dc.contributor.localauthorLim, Dae-Sik-
dc.contributor.nonIdAuthorKoo, Ja Hyun-
dc.contributor.nonIdAuthorPlouffe, Steven W.-
dc.contributor.nonIdAuthorMeng, Zhipeng-
dc.contributor.nonIdAuthorYang, Di-
dc.contributor.nonIdAuthorWang, Cun-Yu-
dc.contributor.nonIdAuthorGuan, Kun-Liang-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorHippo-
dc.subject.keywordAuthorc-fos-
dc.subject.keywordAuthorliver-
dc.subject.keywordAuthorbilirubin-
dc.subject.keywordAuthorhepatomegaly-
dc.subject.keywordAuthorcancer-
dc.subject.keywordPlusHIPPO PATHWAY-
dc.subject.keywordPlusUVEAL MELANOMA-
dc.subject.keywordPlusSIZE-CONTROL-
dc.subject.keywordPlusTRANSCRIPTION FACTORS-
dc.subject.keywordPlusTISSUE HOMEOSTASIS-
dc.subject.keywordPlusYAP ONCOPROTEIN-
dc.subject.keywordPlusC-FOS-
dc.subject.keywordPlusTUMORIGENESIS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusMECHANISM-
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