Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells

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To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-a-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.
Publisher
YONSEI UNIV COLL MEDICINE
Issue Date
2020-01
Language
English
Article Type
Article
Citation

YONSEI MEDICAL JOURNAL, v.61, no.1, pp.100 - 102

ISSN
0513-5796
DOI
10.3349/ymj.2020.61.1.100
URI
http://hdl.handle.net/10203/271178
Appears in Collection
MSE-Journal Papers(저널논문)
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