Large scale comparative interactomics analysis of protein family networks = 단백질 패밀리 네트워크의 대규모 상호작용체 비교 연구

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We carried out an extensive comparative analysis of theoretical interactomes for 146 complete genomes (archaea: 15, bacteria: 122, and eukarya: 9) using a protein structural interactome map method under a homogeneous paradigm: protein family-family interaction networks (an interactome is a set of all protein family interactions within a proteome). All the interactomes were scale-free networks, and the number of interaction pairs increased linearly along with the number of protein families. We found a fundamental difference among prokaryotic and eukaryotic interactomes: eukarya had many more hub families than archaea and bacteria, and certain special hub families characteristically determined the shape of the eukaryotic interactomes. Our finding suggests that a very small number of expansive protein families led the growth of interactomes and seemed to have played a key role in species diversification.
Advisors
Lee, Do-Heonresearcher이도헌researcher
Description
한국과학기술원 : 바이오시스템학과,
Publisher
한국과학기술원
Issue Date
2005
Identifier
249569/325007  / 020033936
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오시스템학과, 2005.8, [ iv, 41 p. ]

Keywords

Comparative Interactomics; 비교상호작용체학

URI
http://hdl.handle.net/10203/27113
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=249569&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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