Locally Activating TrkB Receptor Generates Actin Waves and Specifies Axonal Fate

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dc.contributor.authorWoo, Doyeonko
dc.contributor.authorSeo, Yejiko
dc.contributor.authorJung, Hyunjinko
dc.contributor.authorKim, Sungsooko
dc.contributor.authorKim, Nuryko
dc.contributor.authorPark, Sang-Minko
dc.contributor.authorLee, Heeyoungko
dc.contributor.authorLee, Sangkyuko
dc.contributor.authorCho, Kwang-Hyunko
dc.contributor.authorHeo, Won Doko
dc.date.accessioned2020-01-07T07:20:28Z-
dc.date.available2020-01-07T07:20:28Z-
dc.date.created2020-01-07-
dc.date.created2020-01-07-
dc.date.created2020-01-07-
dc.date.issued2019-12-
dc.identifier.citationCELL CHEMICAL BIOLOGY, v.26, no.12, pp.1652 - +-
dc.identifier.issn2451-9448-
dc.identifier.urihttp://hdl.handle.net/10203/270931-
dc.description.abstractActin waves are filamentous actin (F-actin)-rich structures that initiate in the somato-neuritic area and move toward neurite ends. The upstream cues that initiate actin waves are poorly understood. Here, using an optogenetic approach (Opto-cytTrkB), we found that local activation of the TrkB receptor around the neurite end initiates actin waves and triggers neurite elongation. During actin wave generation, locally activated TrkB signaling in the distal neurite was functionally connected with preferentially localized Rac1 and its signaling pathways in the proximal region. Moreover, TrkB activity changed the location of ankyrinG-the master organizer of the axonal initial segment-and initiated the stimulated neurite to acquire axonal characteristics. Taken together, these findings suggest that local Opto-cytTrkB activation switches the fate from minor to major axonal neurite during neuronal polarization by generating actin waves.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.titleLocally Activating TrkB Receptor Generates Actin Waves and Specifies Axonal Fate-
dc.typeArticle-
dc.identifier.wosid000503739200006-
dc.identifier.scopusid2-s2.0-85076360511-
dc.type.rimsART-
dc.citation.volume26-
dc.citation.issue12-
dc.citation.beginningpage1652-
dc.citation.endingpage+-
dc.citation.publicationnameCELL CHEMICAL BIOLOGY-
dc.identifier.doi10.1016/j.chembiol.2019.10.006-
dc.contributor.localauthorCho, Kwang-Hyun-
dc.contributor.localauthorHeo, Won Do-
dc.contributor.nonIdAuthorWoo, Doyeon-
dc.contributor.nonIdAuthorJung, Hyunjin-
dc.contributor.nonIdAuthorKim, Nury-
dc.contributor.nonIdAuthorLee, Heeyoung-
dc.contributor.nonIdAuthorLee, Sangkyu-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusHIPPOCAMPAL AXONS-
dc.subject.keywordPlusINITIAL SEGMENT-
dc.subject.keywordPlusSODIUM-CHANNELS-
dc.subject.keywordPlusANKYRIN-G-
dc.subject.keywordPlusPOLARITY-
dc.subject.keywordPlusESTABLISHMENT-
dc.subject.keywordPlusMAINTENANCE-
dc.subject.keywordPlusTRANSPORT-
dc.subject.keywordPlusMOTILITY-
dc.subject.keywordPlusNEURONS-
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BiS-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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