High-radix microfluidic multiplexers using pressure valves of different thresholds = 임계압력이 다른 디지털 밸브를 이용한 고진수 유체 분배기

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We propose high-radix microfluidic multiplexers that effectively address a large number of flow channels with a few control lines having pressure valves of different thresholds. Previous binary multiplexers address only two flow channels by controlling identical threshold pressure valves in two control lines; that is, they address $2^{n/2}$ flow channels by using n control lines. However, the proposed high radix multiplexer, ternary or quaternary multiplexer, address three or four flow channels by controlling two or three kinds of valves in two control lines, respectively. Thus, these multiplexers address $3^{n/2}$ and $4^{n/2}$ flow channels, which are results by increasing the radix from binary to quaternary. In experiment, we determined the static/dynamic operating conditions of the pressure valves having different thresholds in the ternary and quaternary multiplexers. Under these conditions, the prototypes such as 3×3 well array, 4×4 well array and digital dilution chip are successfully operated. In well array test, the ternary and quaternary multiplexers selectively fill out 3×3 and 4×4 well array, respectively. In the dilution chip, the ternary multiplexer controls nine valves which dilute sample within 16.7% error and react samples within 17.7% error. Thus, the present high-radix multiplexers reduces the number of control lines for multiple flow channel and valve addressing, achieving effective flow channels control required for simple and compact microfluidic systems.
Advisors
Cho, Young-Horesearcher조영호researcher
Description
한국과학기술원 : 바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2009
Identifier
328482/325007  / 020045860
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 바이오및뇌공학과, 2009. 8., [ x, 104 p. ]

Keywords

Microfluidic Multiplexer; Pressure Valve; 유체 분배기; 압력 밸브; Microfluidic Multiplexer; Pressure Valve; 유체 분배기; 압력 밸브

URI
http://hdl.handle.net/10203/27075
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=328482&flag=dissertation
Appears in Collection
BiS-Theses_Ph.D.(박사논문)
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