Isomagnetophoresis for microfluidic sorting and analysis = 미세입자 분리 및 분석을 위한 미세유체제어 기반 등자기영동 기술 개발

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This thesis presents isomagnetophoresis for microfluidic particle sorting and analysis and successful discrimination results of the subtle difference in the magnetic susceptibility of the polymer particles. Since isomagnetophoresis is based on the conventional magnetophoretic platform, the reliable microfluidic device for magnetophoresis has been established employing the ferromagnetic microstructure. As a demonstration of the magnetophoretic platform, the magnetophoretic purification of single-walled carbon nanotubes (SWCNTs) was carried out in the microfluidic device resulting in about 99.0 % purity. The theoretical analysis model for isomagnetophoresis was defined combining the magnetophoretic velocity, the drag force by Stokes’ law and the fluidic velocity profile in laminar flows. The magnetic susceptibility gradient was generated in the microfluidic channel using gadolinium diethylenetriamine-pentaacetic acid (Gd-DTPA) and D-glucose. In the experiment, the polystyrene (PS; 14.78±0.20 ??m in diameter), poly(methyl methacrylate) (PMMA; 15.00±0.77 ??m) and borosilicate (BS; 14.01±1.00 ??m) microspheres were sorted and analyzed, where the PS and PMMA particles have similar diamagnetic susceptibility that cannot be distinguished by conventional magnetophoresis. This platform can be applied to label-free discrimination of the biological cells and nanotubes.
Advisors
Park, Je-Kyunresearcher박제균researcher
Description
한국과학기술원 : 바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2008
Identifier
295305/325007  / 020045006
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 바이오및뇌공학과, 2008.2, [ xiv, 124 p. ]

Keywords

Isomagnetophoresis; microfluidic device; separation; magnetic susceptibility; 등자기영동; 미세유체소자; 분리; 자기 자화율; Isomagnetophoresis; microfluidic device; separation; magnetic susceptibility; 등자기영동; 미세유체소자; 분리; 자기 자화율

URI
http://hdl.handle.net/10203/27059
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=295305&flag=dissertation
Appears in Collection
BiS-Theses_Ph.D.(박사논문)
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