The present study is mainly motivated to investigate the vaporization, auto-ignition, and combustion of liquid fuel spray injected into high pressure environment. The unsteady, multi-dimensional models were used for realistic simulation of spray as well as prediction of accurate ignition delay time. The Separated Flow (SF) model which considers the finite rate of transport between liquid and gas phases was employed to represent the interactions between spray and gas field. Among the SF models, the Discrete Droplet Model (DDM) which simulates the spray using finite number of representative samples of discrete droplets was adopted. The Eulerian-Lagrangian formulation was used to analyze the two-phase interactions. In order to predict an evaporation rate of droplet in high pressure environment, the high pressure vaporization model was applied using thermodynamic equilibrium and phase equilibrium at droplet surface. The high pressure effect as well as high temperature effect was considered in the calculation of liquid and gas properties. In case of spray vaporization, an interaction between droplets was studied through the comparison with single droplet vaporization. Also, the characteristics of spray behavior in high pressure environment were investigated through the comparison with normal ambient pressure case.