DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Young-Gyun | ko |
dc.contributor.author | Sohn, Chang Ho | ko |
dc.contributor.author | Chen, Ritchie | ko |
dc.contributor.author | McCue, Margaret | ko |
dc.contributor.author | Yun, Dae Hee | ko |
dc.contributor.author | Drummond, Gabrielle T | ko |
dc.contributor.author | Ku, Taeyun | ko |
dc.contributor.author | Evans, Nicholas B | ko |
dc.contributor.author | Oak, Hayeon Caitlyn | ko |
dc.contributor.author | Trieu, Wendy | ko |
dc.contributor.author | Choi, Heejin | ko |
dc.contributor.author | Jin, Xin | ko |
dc.contributor.author | Lilascharoen, Varoth | ko |
dc.contributor.author | Wang, Ji | ko |
dc.contributor.author | Truttmann, Matthias C | ko |
dc.contributor.author | Qi, Helena W | ko |
dc.contributor.author | Ploegh, Hidde L | ko |
dc.contributor.author | Golub, Todd R | ko |
dc.contributor.author | Chen, Shih-Chi | ko |
dc.contributor.author | Frosch, Matthew P | ko |
dc.contributor.author | Kulik, Heather J | ko |
dc.contributor.author | Lim, Byung Kook | ko |
dc.contributor.author | Chung, Kwanghun | ko |
dc.date.accessioned | 2019-12-13T08:23:50Z | - |
dc.date.available | 2019-12-13T08:23:50Z | - |
dc.date.created | 2019-08-06 | - |
dc.date.created | 2019-08-06 | - |
dc.date.created | 2019-08-06 | - |
dc.date.created | 2019-08-06 | - |
dc.date.created | 2019-08-06 | - |
dc.date.created | 2019-08-06 | - |
dc.date.created | 2019-08-06 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.citation | NATURE BIOTECHNOLOGY, v.37, no.1, pp.73 - 83 | - |
dc.identifier.issn | 1087-0156 | - |
dc.identifier.uri | http://hdl.handle.net/10203/269104 | - |
dc.description.abstract | Understanding complex biological systems requires the system-wide characterization of both molecular and cellular features. Existing methods for spatial mapping of biomolecules in intact tissues suffer from information loss caused by degradation and tissue damage. We report a tissue transformation strategy named stabilization under harsh conditions via intramolecular epoxide linkages to prevent degradation (SHIELD), which uses a flexible polyepoxide to form controlled intra- and intermolecular cross-link with biomolecules. SHIELD preserves protein fluorescence and antigenicity, transcripts and tissue architecture under a wide range of harsh conditions. We applied SHIELD to interrogate system-level wiring, synaptic architecture, and molecular features of virally labeled neurons and their targets in mouse at single-cell resolution. We also demonstrated rapid three-dimensional phenotyping of core needle biopsies and human brain cells. SHIELD enables rapid, multiscale, integrated molecular phenotyping of both animal and clinical tissues. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Protection of tissue physicochemical properties using polyfunctional crosslinkers | - |
dc.type | Article | - |
dc.identifier.wosid | 000454804600022 | - |
dc.identifier.scopusid | 2-s2.0-85059605548 | - |
dc.type.rims | ART | - |
dc.citation.volume | 37 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 73 | - |
dc.citation.endingpage | 83 | - |
dc.citation.publicationname | NATURE BIOTECHNOLOGY | - |
dc.identifier.doi | 10.1038/nbt.4281 | - |
dc.contributor.localauthor | Park, Young-Gyun | - |
dc.contributor.localauthor | Sohn, Chang Ho | - |
dc.contributor.localauthor | Ku, Taeyun | - |
dc.contributor.nonIdAuthor | Chen, Ritchie | - |
dc.contributor.nonIdAuthor | McCue, Margaret | - |
dc.contributor.nonIdAuthor | Yun, Dae Hee | - |
dc.contributor.nonIdAuthor | Drummond, Gabrielle T | - |
dc.contributor.nonIdAuthor | Evans, Nicholas B | - |
dc.contributor.nonIdAuthor | Oak, Hayeon Caitlyn | - |
dc.contributor.nonIdAuthor | Trieu, Wendy | - |
dc.contributor.nonIdAuthor | Choi, Heejin | - |
dc.contributor.nonIdAuthor | Jin, Xin | - |
dc.contributor.nonIdAuthor | Lilascharoen, Varoth | - |
dc.contributor.nonIdAuthor | Wang, Ji | - |
dc.contributor.nonIdAuthor | Truttmann, Matthias C | - |
dc.contributor.nonIdAuthor | Qi, Helena W | - |
dc.contributor.nonIdAuthor | Ploegh, Hidde L | - |
dc.contributor.nonIdAuthor | Golub, Todd R | - |
dc.contributor.nonIdAuthor | Chen, Shih-Chi | - |
dc.contributor.nonIdAuthor | Frosch, Matthew P | - |
dc.contributor.nonIdAuthor | Kulik, Heather J | - |
dc.contributor.nonIdAuthor | Lim, Byung Kook | - |
dc.contributor.nonIdAuthor | Chung, Kwanghun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | IN-SITU HYBRIDIZATION | - |
dc.subject.keywordPlus | MOLECULAR-FORCE FIELD | - |
dc.subject.keywordPlus | WHOLE-BODY | - |
dc.subject.keywordPlus | BRAIN ACTIVITY | - |
dc.subject.keywordPlus | CHAIN-REACTION | - |
dc.subject.keywordPlus | INTACT-TISSUE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | AUTOFLUORESCENCE | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.