DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Daseuli | ko |
dc.contributor.author | Lee, Hansol | ko |
dc.contributor.author | Hong, Jongryul | ko |
dc.contributor.author | Jung, Hyunjin | ko |
dc.contributor.author | Jo, YoungJu | ko |
dc.contributor.author | Oh, Byung-Ha | ko |
dc.contributor.author | Park, Byung Ouk | ko |
dc.contributor.author | Heo, Won Do | ko |
dc.date.accessioned | 2019-12-13T07:20:07Z | - |
dc.date.available | 2019-12-13T07:20:07Z | - |
dc.date.created | 2019-12-02 | - |
dc.date.created | 2019-12-02 | - |
dc.date.created | 2019-12-02 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.citation | NATURE METHODS, v.16, no.11, pp.1095 - + | - |
dc.identifier.issn | 1548-7091 | - |
dc.identifier.uri | http://hdl.handle.net/10203/268840 | - |
dc.description.abstract | Intracellular antibodies have become powerful tools for imaging, modulating and neutralizing endogenous target proteins. Here, we describe an optogenetically activated intracellular antibody (optobody) consisting of split antibody fragments and blue-light inducible heterodimerization domains. We expanded this optobody platform by generating several optobodies from previously developed intracellular antibodies, and demonstrated that photoactivation of gelsolin and beta 2-adrenergic receptor (beta 2AR) optobodies suppressed endogenous gelsolin activity and beta 2AR signaling, respectively. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins | - |
dc.type | Article | - |
dc.identifier.wosid | 000493902600019 | - |
dc.identifier.scopusid | 2-s2.0-85074053703 | - |
dc.type.rims | ART | - |
dc.citation.volume | 16 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 1095 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | NATURE METHODS | - |
dc.identifier.doi | 10.1038/s41592-019-0592-7 | - |
dc.contributor.localauthor | Oh, Byung-Ha | - |
dc.contributor.localauthor | Heo, Won Do | - |
dc.contributor.nonIdAuthor | Lee, Hansol | - |
dc.contributor.nonIdAuthor | Hong, Jongryul | - |
dc.contributor.nonIdAuthor | Jung, Hyunjin | - |
dc.contributor.nonIdAuthor | Jo, YoungJu | - |
dc.contributor.nonIdAuthor | Park, Byung Ouk | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
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