Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins

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dc.contributor.authorYu, Daseuliko
dc.contributor.authorLee, Hansolko
dc.contributor.authorHong, Jongryulko
dc.contributor.authorJung, Hyunjinko
dc.contributor.authorJo, YoungJuko
dc.contributor.authorOh, Byung-Hako
dc.contributor.authorPark, Byung Oukko
dc.contributor.authorHeo, Won Doko
dc.date.accessioned2019-12-13T07:20:07Z-
dc.date.available2019-12-13T07:20:07Z-
dc.date.created2019-12-02-
dc.date.created2019-12-02-
dc.date.issued2019-11-
dc.identifier.citationNATURE METHODS, v.16, no.11, pp.1095 - +-
dc.identifier.issn1548-7091-
dc.identifier.urihttp://hdl.handle.net/10203/268840-
dc.description.abstractIntracellular antibodies have become powerful tools for imaging, modulating and neutralizing endogenous target proteins. Here, we describe an optogenetically activated intracellular antibody (optobody) consisting of split antibody fragments and blue-light inducible heterodimerization domains. We expanded this optobody platform by generating several optobodies from previously developed intracellular antibodies, and demonstrated that photoactivation of gelsolin and beta 2-adrenergic receptor (beta 2AR) optobodies suppressed endogenous gelsolin activity and beta 2AR signaling, respectively.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleOptogenetic activation of intracellular antibodies for direct modulation of endogenous proteins-
dc.typeArticle-
dc.identifier.wosid000493902600019-
dc.identifier.scopusid2-s2.0-85074053703-
dc.type.rimsART-
dc.citation.volume16-
dc.citation.issue11-
dc.citation.beginningpage1095-
dc.citation.endingpage+-
dc.citation.publicationnameNATURE METHODS-
dc.identifier.doi10.1038/s41592-019-0592-7-
dc.contributor.localauthorOh, Byung-Ha-
dc.contributor.localauthorHeo, Won Do-
dc.contributor.nonIdAuthorLee, Hansol-
dc.contributor.nonIdAuthorHong, Jongryul-
dc.contributor.nonIdAuthorJung, Hyunjin-
dc.contributor.nonIdAuthorJo, YoungJu-
dc.contributor.nonIdAuthorPark, Byung Ouk-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
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