Relation between speckle decorrelation and optical phase conjugation (OPC)-based turbidity suppression through dynamic scattering media: a study on in vivo mouse skin

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Light scattering in biological tissue significantly limits the accessible depth for localized optical interrogation and deep-tissue optical imaging. This challenge can be overcome by exploiting the time-reversal property of optical phase conjugation (OPC) to reverse multiple scattering events or suppress turbidity. However, in living tissue, scatterers are highly movable and the movement can disrupt time-reversal symmetry when there is a latency in the OPC playback. In this paper, we show that the motioninduced degradation of the OPC turbidity-suppression effect through a dynamic scattering medium shares the same decorrelation time constant as that determined from speckle intensity autocorrelation -a popular conventional measure of scatterer movement. We investigated this decorrelation characteristic time through a 1.5-mm-thick dorsal skin flap of a living mouse and found that it ranges from 50 ms to 2.5 s depending on the level of immobilization. This study provides information on relevant time scales for applying OPC to living tissues. (C) 2014 Optical Society of America
Publisher
OPTICAL SOC AMER
Issue Date
2015-01
Language
English
Article Type
Article
Citation

BIOMEDICAL OPTICS EXPRESS, v.6, no.1, pp.72 - 85

ISSN
2156-7085
DOI
10.1364/BOE.6.000072
URI
http://hdl.handle.net/10203/268700
Appears in Collection
BiS-Journal Papers(저널논문)
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