Focusing through dynamic tissue with millisecond digital optical phase conjugation

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Digital optical phase conjugation (DOPC) is a new technique employed in wavefront shaping and phase conjugation for focusing light through or within scattering media such as biological tissues. DOPC is particularly attractive as it intrinsically achieves a high fluence reflectivity in comparison to nonlinear optical approaches. However, the slow refresh rate of liquid crystal spatial light modulators and limitations imposed by computer data transfer speeds have thus far made it difficult for DOPC to achieve a playback latency of shorter than similar to 200 ms and, therefore, prevented DOPC from being practically applied to thick living samples. In this paper, we report a novel DOPC system that is capable of 5.3 ms playback latency. This speed improvement of almost 2 orders of magnitude is achieved by using a digital micromirror device, field programmable gate array (FPGA) processing, and a single-shot binary phase retrieval technique. With this system, we are able to focus through 2.3 mm living mouse skin with blood flowing through it (decorrelation time similar to 30 ms) and demonstrate that the focus can be maintained indefinitely-an important technological milestone that has not been previously reported, to the best of our knowledge. (C) 2015 Optical Society of America
Publisher
OPTICAL SOC AMER
Issue Date
2015-08
Language
English
Article Type
Article
Citation

OPTICA, v.2, no.8, pp.728 - 735

ISSN
2334-2536
DOI
10.1364/OPTICA.2.000728
URI
http://hdl.handle.net/10203/268699
Appears in Collection
BiS-Journal Papers(저널논문)
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