Dynamically changing neuronal activity supporting working memory for predictable and unpredictable durations

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Diverse neural processes have been proposed as the neural basis of working memory. To investigate whether the medial prefrontal cortex (mPFC) relies on different neural processes to mediate working memory depending on the predictability of delay duration, we examined mPFC neural activity in mice performing a delayed response task with fixed (4 s) or random (between 1-7 s) delay durations. mPFC neural activity was strongly influenced by the predictability of delay duration. Nevertheless, mPFC neurons seldom showed persistent activity spanning the entire delay period and instead showed dynamically-changing delay-period activity under both the fixed-delay and random-delay conditions. mPFC neurons conveyed higher working memory information under the random-delay than fixed-delay conditions, possibly due to a higher demand for stable working memory maintenance. Our results suggest that the rodent mPFC may rely on dynamically-changing neuronal activity to maintain working memory regardless of the predictability of delay duration.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2019-10
Language
English
Article Type
Article
Citation

SCIENTIFIC REPORTS, v.9

ISSN
2045-2322
DOI
10.1038/s41598-019-52017-8
URI
http://hdl.handle.net/10203/268314
Appears in Collection
BS-Journal Papers(저널논문)
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