DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Chae Won | ko |
dc.contributor.author | Yoo, Hye Jee | ko |
dc.contributor.author | Park, Jang Hyun | ko |
dc.contributor.author | Oh, Ji Eun | ko |
dc.contributor.author | Lee, Heung Kyu | ko |
dc.date.accessioned | 2019-10-24T07:20:37Z | - |
dc.date.available | 2019-10-24T07:20:37Z | - |
dc.date.created | 2019-10-22 | - |
dc.date.created | 2019-10-22 | - |
dc.date.created | 2019-10-22 | - |
dc.date.created | 2019-10-22 | - |
dc.date.created | 2019-10-22 | - |
dc.date.created | 2019-10-22 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.citation | VIRUSES-BASEL, v.11, no.9 | - |
dc.identifier.issn | 1999-4915 | - |
dc.identifier.uri | http://hdl.handle.net/10203/268057 | - |
dc.description.abstract | Influenza is an infectious respiratory illness caused by the influenza virus. Though vaccines against influenza exist, they have limited efficacy. To additionally develop effective treatments, there is a need to study the mechanisms of host defenses from influenza viral infections. To date, the mechanism by which interleukin (IL)-33 modulates the antiviral immune response post-influenza infection is unclear. In this study, we demonstrate that exogenous IL-33 enhanced antiviral protection against influenza virus infection. Exogenous IL-33 induced the recruitment of dendritic cells, increased the secretion of pro-inflammatory cytokine IL-12, and promoted cytotoxic T-cell responses in the local microenvironment. Thus, our findings suggest a role of exogenous IL-33 in the antiviral immune response against influenza infection. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Exogenous Interleukin-33 Contributes to Protective Immunity via Cytotoxic T-Cell Priming against Mucosal Influenza Viral Infection | - |
dc.type | Article | - |
dc.identifier.wosid | 000487962400019 | - |
dc.identifier.scopusid | 2-s2.0-85072148077 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 9 | - |
dc.citation.publicationname | VIRUSES-BASEL | - |
dc.identifier.doi | 10.3390/v11090840 | - |
dc.contributor.localauthor | Oh, Ji Eun | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | IL-33 | - |
dc.subject.keywordAuthor | influenza virus | - |
dc.subject.keywordAuthor | antiviral immunity | - |
dc.subject.keywordPlus | IL-33 | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | VACCINES | - |
dc.subject.keywordPlus | PROMOTE | - |
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