Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets

Cited 5 time in webofscience Cited 0 time in scopus
  • Hit : 164
  • Download : 21
DC FieldValueLanguage
dc.contributor.authorKwak, Jeong-Eunko
dc.contributor.authorKim, Young-Ilko
dc.contributor.authorPark, Su-Jinko
dc.contributor.authorYu, Min-Ahko
dc.contributor.authorKwon, Hyeok-Ilko
dc.contributor.authorEo, Sukyeongko
dc.contributor.authorKim, Tae-Shinko
dc.contributor.authorSeok, Joonko
dc.contributor.authorChoi, Won-Sukko
dc.contributor.authorJeong, Ju Hwanko
dc.contributor.authorLee, Hyojinko
dc.contributor.authorCho, Youngranko
dc.contributor.authorKwon, Jin Ahko
dc.contributor.authorJeong, Moonsupko
dc.contributor.authorMaslow, Joel N.ko
dc.contributor.authorKim, Yong-Eunko
dc.contributor.authorJeon, Hailiko
dc.contributor.authorKim, Kee K.ko
dc.contributor.authorShin, Eui-Cheolko
dc.contributor.authorSong, Min-Sukko
dc.contributor.authorJung, Jae U.ko
dc.contributor.authorChoi, Young Kiko
dc.contributor.authorPark, Su-Hyungko
dc.date.accessioned2019-09-10T02:20:36Z-
dc.date.available2019-09-10T02:20:36Z-
dc.date.created2019-09-09-
dc.date.created2019-09-09-
dc.date.issued2019-08-
dc.identifier.citationNATURE COMMUNICATIONS, v.10, pp.3836-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10203/267430-
dc.description.abstractAlthough the incidence of severe fever with thrombocytopenia syndrome virus (SFTSV) infection has increased from its discovery with a mortality rate of 10-20%, no effective vaccines are currently available. Here we describe the development of a SFTSV DNA vaccine, its immunogenicity, and its protective efficacy. Vaccine candidates induce both a neutralizing antibody response and multifunctional SFTSV-specific T cell response in mice and ferrets. When the vaccine efficacy is investigated in aged-ferrets that recapitulate fatal clinical symptoms, vaccinated ferrets are completely protected from lethal SFTSV challenge without developing any clinical signs. A serum transfer study reveals that anti-envelope antibodies play an important role in protective immunity. Our results suggest that Gn/Gc may be the most effective antigens for inducing protective immunity and non-envelope-specific T cell responses also can contribute to protection against SFTSV infection. This study provides important insights into the development of an effective vaccine, as well as corresponding immune parameters, to control SFTSV infection.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleDevelopment of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets-
dc.typeArticle-
dc.identifier.wosid000482398900038-
dc.identifier.scopusid2-s2.0-85071340650-
dc.type.rimsART-
dc.citation.volume10-
dc.citation.beginningpage3836-
dc.citation.publicationnameNATURE COMMUNICATIONS-
dc.identifier.doi10.1038/s41467-019-11815-4-
dc.contributor.localauthorShin, Eui-Cheol-
dc.contributor.localauthorPark, Su-Hyung-
dc.contributor.nonIdAuthorKwak, Jeong-Eun-
dc.contributor.nonIdAuthorKim, Young-Il-
dc.contributor.nonIdAuthorPark, Su-Jin-
dc.contributor.nonIdAuthorYu, Min-Ah-
dc.contributor.nonIdAuthorKwon, Hyeok-Il-
dc.contributor.nonIdAuthorKim, Tae-Shin-
dc.contributor.nonIdAuthorChoi, Won-Suk-
dc.contributor.nonIdAuthorJeong, Ju Hwan-
dc.contributor.nonIdAuthorLee, Hyojin-
dc.contributor.nonIdAuthorCho, Youngran-
dc.contributor.nonIdAuthorKwon, Jin Ah-
dc.contributor.nonIdAuthorJeong, Moonsup-
dc.contributor.nonIdAuthorMaslow, Joel N.-
dc.contributor.nonIdAuthorKim, Yong-Eun-
dc.contributor.nonIdAuthorJeon, Haili-
dc.contributor.nonIdAuthorKim, Kee K.-
dc.contributor.nonIdAuthorSong, Min-Suk-
dc.contributor.nonIdAuthorJung, Jae U.-
dc.contributor.nonIdAuthorChoi, Young Ki-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusTHROMBOCYTOPENIA SYNDROME VIRUS-
dc.subject.keywordPlusSEVERE FEVER-
dc.subject.keywordPlusSOUTH-KOREA-
dc.subject.keywordPlusBUNYAVIRUS-
dc.subject.keywordPlusPATHOGENESIS-
dc.subject.keywordPlusELECTROPORATION-
dc.subject.keywordPlusTRANSMISSION-
dc.subject.keywordPlusMODEL-
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 5 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0