Light-harvesting alginate hydrogel for sustainable photobiocatalysis = 광수확 알긴산 하이드로젤을 이용한 지속 가능한 생체촉매 기반 광합성 연구

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dc.contributor.advisorPark, Chan Beum-
dc.contributor.advisor박찬범-
dc.contributor.authorYoon, Jaeho-
dc.date.accessioned2019-09-03T02:45:40Z-
dc.date.available2019-09-03T02:45:40Z-
dc.date.issued2019-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=843308&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/266452-
dc.description학위논문(석사) - 한국과학기술원 : 신소재공학과, 2019.2,[iv, 38 p. :]-
dc.description.abstractWe report visible light-driven, asymmetric hydrogenation of C=C bonds using an ene-reductase from Thermus scotoductus SA-01 (TsOYE) and a light-harvesting dye (rose bengal, RB) co-immobilized in alginate hydrogel. Highly efficient encapsulation of RB in alginate hydrogel was achieved using the intrinsic affinity between TsOYE and RB, which allowed for the construction of robust RB-TsOYE-loaded alginate capsules. In the absence of NADH, the photobiocatalytic system facilitated asymmetric reduction of 2-methylcyclohexenone to an enantiopure (R)-2-methylcyclohexanone (ee>99%, max. conversion: 70.4%, turnover frequency: 1.54 $min^{-1}$, turnover number: 300.2) under illumination. A series of stability tests revealed a significant enhancement of TsOYE's robustness in alginate hydrogel against heat and chemical denaturants. This study provides insight into a greener and sustainable approach of cofactor-free OYE catalysis for producing value-added chemicals using light energy.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectphotobiocatalysis▼aene-reductase▼aasymmetric hydrogenation▼aNADH-free bioprocess▼aalginate hydrogel-
dc.subject구황색 효소▼a탄소 이중결합 비대칭 환원▼a광생체촉매반응▼a니코틴아마이드 보조인자 부재 생체촉매반응▼a알긴산 하이드로젤-
dc.titleLight-harvesting alginate hydrogel for sustainable photobiocatalysis = 광수확 알긴산 하이드로젤을 이용한 지속 가능한 생체촉매 기반 광합성 연구-
dc.typeThesis(Master)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :신소재공학과,-
dc.contributor.alternativeauthor윤재호-
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