Complex interaction among multiple dsRNA binding proteins is critical for chemotherapy using decitabine = 데시타빈을 이용한 항암 약물 치료에서 RNA 결합 단백질 간의 상호작용 연구

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Although last decades studies, the cancer treatment is still incomplete. Also, the decitabine (DAC) have shown clinical anti-cancer efficacy but their mechanism of action is unclear. Identification of the mechanism of drugs is necessary for effective chemotherapy. Here, we investigate the mechanism that how does DAC treatment lead to apoptosis. Recent studies have shown that DAC treatment results in increased expression of ERVs, which induces apoptosis by activating MDA5 [1]. We find that another immune response protein PKR can also bind to ERVs and is involved in DAC-mediated cell death. In addition, we show that DAC treatment causes increased expression of many noncoding RNAs that can act as dsRNAs to activate immune response proteins. Furthermore, using RNAi screening system, we examined the contribution of different dsRNA binding proteins (dsRBPs) in the effectiveness of the DAC treatment. Our study reveals that DAC-mediated apoptosis is a consequence of complex interactions among different dsRBPs for access to their commonly binding noncoding dsRNAs.
Advisors
Kim, Yoosikresearcher김유식researcher
Description
한국과학기술원 :생명화학공학과,
Publisher
한국과학기술원
Issue Date
2018
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2018.8,[iii, 28 p. :]

Keywords

cancer▼adecitabine▼adouble-stranded RNA▼adouble-stranded RNA binding proteins▼achemotherapy; 암▼a데시타빈▼a이중 가닥 RNA▼a이중 가닥 RNA 결합 단백질▼a약물 치료

URI
http://hdl.handle.net/10203/266303
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=828514&flag=dissertation
Appears in Collection
CBE-Theses_Master(석사논문)
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