We have designed, fabricated and characterized the thermo-pneumatic adhesive pads, where heaters are fabricated in chambers for skin-to-pad adhesion control. The thermo-pneumatic adhesive pads control temperature and pressure of the chamber air. The heater temperature changes the pressure in the chambers; thus, increasing or decreasing the skin-pad adhesion force. In the experimental study, we characterize the adhesion force from three different pads: SU8 flat pad, SU8 pad with chambers, and SU8 pad with chambers and heaters. In the pad with chambers and heaters, the heaters increase the adhesion force in the amount of 394.2 % and decrease the adhesion force in the amount of 170.6 %, compared to the pad with chambers. The thermo-pneumatic adhesive pads show the adhesion force sensitivity of 81 mN/W in attachment mode and the adhesion force sensitivity of 33 mN/W in detachment mode, respectively. We have experimentally demonstrated that the thermo-pneumatic adhesive pads are capable to control the skin-pad adhesion force. The adhesion force is increased in pad attachment mode, while decreasing in pad detachment mode without skin damage. The adhesion force of 0.7 N, achieved at the input power of 1.66 W, bears the pad weight of 30 mN and resists the wind force of 6 mN generated at the speed of 100km/h. The thermo-pneumatic adhesive pads are applicable to skin attachable physiological signal monitoring devices.