Development of urinary extracellular vesicles as a drug delivery system = 소변 유래 세포 외 소포체를 이용한 약물 전달체 개발

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In the field of biomedicine, development of a drug delivery system that ensures stability of cargo, biocompatibility, and therapeutic efficacy has been an important task. In this study, we evaluated urinary extracellular vesicles (UEVs) derived from murine urine, and investigated its potential as carriers for drug delivery for the first time. UEVs were delivered to various types of cells from 4T1, mouse brain endothelial, and RAW 264.7 cell lines. They were taken up by the cells significantly, indicating the possibility of its use for a wide spectrum of disease targets. Tumor accumulation of UEVs when compared to control liposomes was seen for intravenous administration. Here, we showed that UEVs has potential as a drug-carrier for personalized medicine due to its great yield, biocompatibility, and stability in vivo.
Advisors
Park, Jihoresearcher박지호researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2017.2,[iii, 36 p. :]

Keywords

drug delivery system▼aextracellular vesicles▼aexosomes▼aurine▼aurinary extracellular vesicles; 약물 전달 시스템▼a세포 외 소포체▼a엑소좀▼a소변▼a소변 유래 세포 외 소포체

URI
http://hdl.handle.net/10203/266167
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=867006&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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