Drug delivery system to employ macrophages as drug-loaded exosome donors대식세포를 약물 탑재 엑소좀 증여자로 이용하기 위한 약물전달 시스템 개발

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dc.contributor.advisor박지호-
dc.contributor.advisorPark, Ji-Ho-
dc.contributor.author이윤수-
dc.date.accessioned2019-09-03T02:40:41Z-
dc.date.available2019-09-03T02:40:41Z-
dc.date.issued2018-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=828493&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/266161-
dc.description학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2018.8,[iii, 31 p. :]-
dc.description.abstractMost of nanoparticles for cancer therapy is cleared in liver without reaching target cells because of phagocytosis of macrophages. Attention to nanoparticles which are not uptaken by macrophages has been uprising to overcome this limitation. However, still large proportion of injected nanoparticles is cleared by macrophages, and complete avoidance of macrophage is very challenging. In this study, we researched the possibility to compensate the efficiency of delivery inducing macrophages to secrete uptaken cargo of nanoparticle, packaged in exosomes. We tried to increase the amount of re-excreted cargo by adding ceramide family lipid, which is known to induce cells to secrete exosomes, to nanoparticle liposome composition. We showed that ceramide family lipid contained in liposome enhanced the exosome secretion of macrophage and increased the amount of liposome cargo in exosome. Furthermore, we also showed that the increase of secreted material via exosomes can result in the enhancement of delivery to tumor cells.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subject약물 전달▼a리포좀▼a나노 소재▼a대식세포▼a엑소좀▼a세라마이드-
dc.subjectdrug delivery▼aliposome▼amanomaterial▼aacrophage▼aexosome▼aceramide-
dc.titleDrug delivery system to employ macrophages as drug-loaded exosome donors-
dc.title.alternative대식세포를 약물 탑재 엑소좀 증여자로 이용하기 위한 약물전달 시스템 개발-
dc.typeThesis(Master)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :바이오및뇌공학과,-
dc.contributor.alternativeauthorLee, Yunsoo-
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