Drug delivery system to employ macrophages as drug-loaded exosome donors = 대식세포를 약물 탑재 엑소좀 증여자로 이용하기 위한 약물전달 시스템 개발

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Most of nanoparticles for cancer therapy is cleared in liver without reaching target cells because of phagocytosis of macrophages. Attention to nanoparticles which are not uptaken by macrophages has been uprising to overcome this limitation. However, still large proportion of injected nanoparticles is cleared by macrophages, and complete avoidance of macrophage is very challenging. In this study, we researched the possibility to compensate the efficiency of delivery inducing macrophages to secrete uptaken cargo of nanoparticle, packaged in exosomes. We tried to increase the amount of re-excreted cargo by adding ceramide family lipid, which is known to induce cells to secrete exosomes, to nanoparticle liposome composition. We showed that ceramide family lipid contained in liposome enhanced the exosome secretion of macrophage and increased the amount of liposome cargo in exosome. Furthermore, we also showed that the increase of secreted material via exosomes can result in the enhancement of delivery to tumor cells.
Advisors
박지호researcherPark, Ji-Horesearcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2018
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2018.8,[iii, 31 p. :]

Keywords

약물 전달▼a리포좀▼a나노 소재▼a대식세포▼a엑소좀▼a세라마이드; drug delivery▼aliposome▼amanomaterial▼aacrophage▼aexosome▼aceramide

URI
http://hdl.handle.net/10203/266161
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=828493&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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