Drug delivery system for extracellular vesicle-mediated antigen-specific immunomodulation = 세포외소포체 매개 항원특이적 면역조절을 위한 약물전달 시스템 개발

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The efforts for the immunomodulation which induce safe tolerance for treating autoimmune diseases have been expanded. Since widely used immunosuppressive drugs have impact on global immune system, they could cause susceptibility to infection and malignancy. In order to avoid the universal effects of drugs, auto-antigens have been used for inducing antigen-specific immune regulation. However, the auto-antigens are mostly not identified and repeated antigen administration could evoke inflammatory response to pathogenic tissues, which make exogenous auto-antigen challenging to transit into clinics. The purpose of this thesis was to develop the anti-inflammatory drug delivery system which can target cells producing auto-antigens and engineer extracellular vesicles to be loaded with antigens and drugs together. We assumed that this naturally secreted EVs which carry antigens and drugs can induce antigen specific immune regulation. Membrane fusogenic liposomes were used to deliver drugs, dexamethasone, to cell membranes. The release of antigens and drugs via EVs were identified and they successfully transferred to dendritic cells. Finally, we showed that transferred EVs induced phenotypic change in DCs, reducing the expression of costimulatory molecules.
Advisors
Park, Ji Horesearcher박지호researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2018
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2018.2,[iii, 40 p. :]

Keywords

autoimmune▼aantigen-specific immunomodulation▼amembrane fusogenic liposome▼adexamethasone extracellular vesicle; 자가면역▼a항원특이적 면역조절▼a막결합성 리포좀▼a덱사메타손▼a세포외소포체

URI
http://hdl.handle.net/10203/266160
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=734181&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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