DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Lee, Jie-Oh | - |
dc.contributor.advisor | 이지오 | - |
dc.contributor.advisor | Kim, Ho Min | - |
dc.contributor.advisor | 김호민 | - |
dc.contributor.author | Won, Seoung Youn | - |
dc.date.accessioned | 2019-08-25T02:50:43Z | - |
dc.date.available | 2019-08-25T02:50:43Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=828257&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/265483 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 화학과, 2018.8,[iii, 52p :] | - |
dc.description.abstract | The leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that direct axonal growth and neuronal regeneration. LAR-RPTPs have drawn particular attentions as presynapse organizers orchestrating synaptic connectivity and development. LAR-RPTPs form trans-synaptic adhesion complexes by binding to various postsynaptic adhesion ligands, such as Slitrks, IL1RAPL1, IL-1RAcP, TrkC and SALMs to regulate synaptogenesis. Here, we determined the crystal structure of the human LAR-RPTP/IL1RAPL1 complex and found that lateral interactions between neighboring LAR-RPTP/IL1RAPL1 complexes in crystal lattices are critical for the higher-order assembly and synaptogenic activity of these complexes. Moreover, we found that LAR-RPTP binding to the postsynaptic adhesion ligands, Slitrk3, IL1RAPL1 and IL-1RAcP, but not TrkC, induces reciprocal higher-order clustering of trans-synaptic adhesion complexes. Although LAR-RPTP clustering was induced by either HS or postsynaptic adhesion ligands, the dominant binding of HS to the LAR-RPTP was capable of dismantling pre-established LAR-RPTP-mediated trans-synaptic adhesion complexes. These findings collectively suggest that LAR-RPTP clustering for synaptogenesis is modulated by a complex synapse-organizing protein network. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | LAR-RPTPs▼apostsynaptic adhesion partners▼asynaptic adhesion molecules▼aheparan sulfate▼ahigher-order clustering | - |
dc.subject | LAR-RPTPs▼a시냅스 후 리간드▼a시냅스 접착 단백질▼a헤파란 설페이트▼a클러스터링 | - |
dc.title | LAR-RPTP clustering modulated by competitive binding between synaptic adhesion partners and heparan sulfate | - |
dc.title.alternative | 헤파란 설페이트와 시냅스 후 리간드에 의한 LAR-RPTP 클러스터링 조절 기전 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :화학과, | - |
dc.contributor.alternativeauthor | 원성연 | - |
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