DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Ho Min | - |
dc.contributor.advisor | 김호민 | - |
dc.contributor.advisor | Kang, Myoung Goo | - |
dc.contributor.advisor | 강명구 | - |
dc.contributor.author | Seo, Bo Am | - |
dc.date.accessioned | 2019-08-25T02:43:37Z | - |
dc.date.available | 2019-08-25T02:43:37Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=827941&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/265112 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 의과학학제전공, 2018.8,[vi, 88 p. :] | - |
dc.description.abstract | Dynamic trafficking of AMPA-type glutamate receptor (AMPA-R) in neuronal cells is a key cellular mechanism for learning and memory in the brain, which is regulated by AMPA-R interacting proteins. Although several postsynaptic proteins that interact with the AMPA-R have been identified as potential regulator of AMPA-R trafficking, the precise mechanism for the modulation of AMPA-R trafficking in and out of synapse is still under investigation. Here, we performed the precise functional study of LARGE, novel interactor of AMPA-R, revealed through our proteomic analysis. Also, we have identified Cav subunit that mediated the interaction between $Ca_v$ and AMPA-R, which can examine their functional association in postsynaptic membrane. Our functional study of LARGE, an intellectual disability-associated protein, indicates that the fine-tuning of AMPA-R trafficking by it as a molecule linking Hebbian and homeostatic synaptic plasticity, which is critical for memory stability is critical for memory formation in the brain. Next, The functional association of Cav2 with AMPA-type glutamate receptor (AMPA-R) in the postsynaptic membrane was mentioned in our previous study. Here, we have identified Cav subunit ($\alpha 1$) that mediates the interaction between Cav2 and AMPA-R through a series of biochemical experiments. which can increases the cell surface localization of AMPA-R. Altogether, our study identified molecular mechanisms underlying the regulation ofA MPA-type glutamate receptor trafficking by its interacting proteins for synaptic plasticity and memory. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Excitatory neurotransmission▼alearning and memory▼aintellectual disability▼asynaptic plasticity▼aAMPA receptor▼aLARGE▼along-term potentiation▼acalcium channel▼a$\alpha 1$ | - |
dc.subject | 흥분성 신경전달▼a학습과 기억▼a지적 장애▼a시냅스 가소성▼a앰파-타입 글루타메이트 수용체▼a라지▼a장기 강화▼a칼슘 채널▼a알파-1 단위체 | - |
dc.title | Molecular mechanisms underlying the regulation of AMPA-type glutamate receptor trafficking by its interacting proteins for synaptic plasticity and memory | - |
dc.title.alternative | 시냅스 가소성과 기억현상을 위한 앰파-타입 글루타메이트 수용체의 이동에 관여하는 단백질들의 역할을 분자적 수준에서 규명 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :의과학학제전공, | - |
dc.contributor.alternativeauthor | 서보암 | - |
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