DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Koh, Gou Young | - |
dc.contributor.advisor | 고규영 | - |
dc.contributor.advisor | Choi, Eun Kyung | - |
dc.contributor.advisor | 최은경 | - |
dc.contributor.author | Park, Intae | - |
dc.date.accessioned | 2019-08-25T02:43:35Z | - |
dc.date.available | 2019-08-25T02:43:35Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=827938&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/265110 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 의과학학제전공, 2018.8,[iv, 75 p. :] | - |
dc.description.abstract | Clinical trials in recent years have tested the combined anti-tumor effects of radiotherapy and anti-VEGF-A therapy, but its clinical benefit of increased overall survival has been proven to be insufficient. In this study, I rationalized and investigated the benefit of combining VEGF-Grab, an anti-angiogenic drug that inhibits VEGF-A and PlGF, with radiotherapy for anti-cancer therapy. By in vitro and human sample analyses, I showed that PlGF is increased in response to radiotherapy. Then, using a syngeneic mouse tumor model, I demonstrated the most potent anti-tumor effects of combined VEGF-Grab and radiation treatment, which was achieved partially by tumor vessel normalization and polarization of tumor-associated macrophages to anti-tumorigenic M1-type. Finally, I showed that VEGF-Grab is not only efficacious but also more effective than a previous developed anti-angiogenic drug, VEGF-Trap, in human xenograft model. In conclusion, this study suggests VEGF-Grab as a viable therapeutic option in the context of inhibiting secondarily activated pathways, specifically in combination with radiotherapy. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | VEGF-Grab▼a방사선치료▼a암 혈관 생성 억제▼aVEGF-A▼aPlGF | - |
dc.subject | VEGF-Grab▼aradiotherapy▼aanti-angiogenesis▼aVEGF-A▼aPlGF | - |
dc.title | Simultaneous targeting of VEGF-A and PlGF by VEGF-Grab potentiates the anti-tumor effect of radiation therapy | - |
dc.title.alternative | VEGF-Grab에 의한 VEGF-A와 PlGF 동시 억제가 종양 방사선치료에 미치는 영향에 대한 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :의과학학제전공, | - |
dc.contributor.alternativeauthor | 박인태 | - |
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