Citron kinase interacts with LATS2 and inhibits LATS2 activity by occluding its hydrophobic phosphorylation motif = LATS2와의 결합과 소수성 인산화 모티프 격리를 통한 Citron kinase의 LATS2 활성 억제

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Large tumor suppressor kinase (LATS2) activity has been shown to be essential to maintain tissue homeostasis by inhibiting the activity of oncoprotein Yes-associated protein (YAP). Many studies have indicated that several new regulators were involved in this process. Citron kinase (CIT) was found to be connected with many components of the Hippo pathway, suggesting a possible function of CIT in regulating the Hippo pathway. However, the molecular mechanism of CIT remains poorly understood, except CIT’s role in cytokinesis. Here, we propose a model in which CIT acts as a scaffold protein linking LATS2 and YAP. Furthermore, our data highlight that CIT binds to and suppresses LATS2 phosphorylation at the hydrophobic motif targeted by MST1. Consequently, LATS2 becomes inactive and YAP is active. Additionally, we found that Sticky, the CIT homolog in Drosophila melanogaster, synergized with Warts to control eye development. Taken together, our study supports a new role of citron kinase as a novel regulator of the Hippo pathway.
Advisors
Park, Chankyuresearcher박찬규researcherLim Dae-Sikresearcher임대식researcher
Description
한국과학기술원 :생명과학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명과학과, 2019.2,[iv, 57 p. :]

Keywords

Citron kinase▼aLATS2-YAP interaction▼aLATS2 inhibition▼asticky-warts; Citron kinase; LATS2-YAP 결합; LATS2 활성억제; Sticky-Warts

URI
http://hdl.handle.net/10203/264787
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842109&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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