Neurofibromatosis 2 (Nf2) is a key determinant for differential growth of optic neuroepithelial compartments = 시각 상피 조직의 차등 성장에 있어 Nf2의 역할 탐구

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Vertebrate eye development accompanies regional diversification of proliferative potential in the optic neuroepithelium, which is partitioned into three compartments?the retina, retinal pigment epithelium (RPE), and ciliary margin zone (CMZ). In this study, I investigated the functions of mouse neurofibromatosis 2 (Nf2), in the development of optic neuroepithelium-derived tissues. I found that the loss of Nf2 in the optic neuroepithelium lead to microphthalmia. Also, structural defects resulted from severe overgrowth of the pigmented cell population in the RPE. I also found that Nf2-deficiency resulted in a hyperplasic CMZ and expansion of CMZ-derived retinal precursor cells. Using a genetic approach, I demonstrated that Nf2, in the RPE and CMZ, is necessary for limiting Yap/Taz activity via the Hippo pathway. Finally, I provide evidences on the transcriptional regulation of Nf2 expression by microphthalmia-inducing transcription factor (Mitf) in the RPE, and by sex-determining region Y-box 2 (Sox2) in the CMZ (and neural retina). Collectively, this study reveals that Nf2 is a key regulator that differentiates the growth of the optic neuroepithelium for achieving proper eye development.
Advisors
Kim, Jin Wooresearcher김진우researcher
Description
한국과학기술원 :생명과학과,
Publisher
한국과학기술원
Issue Date
2018
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명과학과, 2018.2,[135 p. :]

Keywords

ciliary margin▼aHippo pathway▼aneurofibromatosis 2 (Nf2)▼aretina▼aretinal pigment epithelium (RPE); neurofibromatosis 2 (Nf2)▼aHippo 신호 전달 체계▼a망막▼a망막 색소 상피질▼a섬모 변연부

URI
http://hdl.handle.net/10203/264778
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=734313&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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