DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Eunjoon | - |
dc.contributor.advisor | 김은준 | - |
dc.contributor.author | Li, Yan | - |
dc.date.accessioned | 2019-08-22T02:43:30Z | - |
dc.date.available | 2019-08-22T02:43:30Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=849263&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/264772 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2015.2,[vi, 71 p. :] | - |
dc.description.abstract | Synaptic adhesion molecules play critical roles in diverse aspects of synapse development. SALM3 is a PSD-95-interacting synaptic adhesion molecule known to induce presynaptic differentiation in contacting axons, but little is known about its presynaptic receptors and in vivo functions. Here I identify a novel interaction between SALM3 and LAR family receptor protein tyrosine phosphatases (LAR-RPTPs) that requires the mini-exon B splice insert in LAR-RPTPs. In addition, I found SALM3-dependent presynaptic differentiation requires all three types of LAR-RPTPs. Interestingly, in mice lacking SALM3 ($Salm3^{-/-}$), excitatory synapse number is markedly reduced in the hippocampal CA1 region, but synaptic plasticity is normal. Locomotion in both novel and familiar environments is also suppressed in $Salm3^{-/-}$ mice, but learning and memory behaviors are unchanged. These results suggest that SALM3 critically regulates excitatory synapses and locomotion behavior, and that a marked reduction in excitatory synapse number, as long as the remaining synapses have normal plasticity, has little effect on learning and memory. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Synaptic adhesion molecules▼asynapses▼aSALMs▼asynaptic plasticity | - |
dc.subject | 접착 단백질 | - |
dc.subject | 시냅스 | - |
dc.subject | 살름▼a시냅스가소성 | - |
dc.title | Regulation of synapse development by the SALM3 synaptic adhesion molecule | - |
dc.title.alternative | SALM3 synaptic cell adhesion molecule에 의한 시냅스 발달 조절에 관한 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명과학과, | - |
dc.contributor.alternativeauthor | 리얀 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.