(A) study on targeting mechanotransduction using gastric cancer microenvironment-mimetic platforms = 위암 미세환경 모사 플랫폼을 이용한 세포역학신호 타겟 위암 악성화 억제에 관한 연구

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Tumor microenvironment in cancer is influenced by the interaction of the cell with physicochemical and mechanical signals of the extracellular matrix (ECM). It has been reported the development and metastasis of cancer are regulated by mechanical stimuli, and changes in mechanotransduction signaling by bio-mechanical cues are closely related to cancer malignancy. In particular, physicochemical characteristics of ECM in gastric cancer (GC) significantly altered, however, there is no study on the mechanotransduction. Therefore, we developed a new cancer therapeutic approach by analyzing ECM-specific mechanotransduction mechanism and GC malignancy. For this study, 1) we established a physiologically-relevant 3-dimensional (3D) culture model by analyzing ECM characteristics of GC tissues, 2) analyzed mechanotransduction signaling of GC cells according to the physical characteristics of ECM, and 3) finally developed a new cancer therapy strategy by targeting mechanotransduction.
Advisors
Kim, Pilnamresearcher김필남researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 바이오및뇌공학과, 2019.2,[ix, 125 p. :]

Keywords

Tumor microenvironment▼amechanotransduction▼aextracellular matrix▼agastric cancer▼amechanotherapy; 암 미세환경▼a세포역학신호▼a세포외기질▼a위암▼a기계적치료법

URI
http://hdl.handle.net/10203/264679
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842472&flag=dissertation
Appears in Collection
BiS-Theses_Ph.D.(박사논문)
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