Tissue derived extracellular matrix-based in vitro brain tumor model = 생체조직 유래 세포외기질 기반의 체외 뇌암모델 개발 및 활용에 대한 연구

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The cancer cells in brain tumors interact with their microenvironment, which includes stromal cells, the extracellular matrix (ECM), and the physical properties of tissues. The reciprocal interaction between cancer cells and the surrounding microenvironment regulates the biological behavior of cancer cells. To improve our understanding of the progression of brain tumors, it is useful to construct physiologically relevant brain tumor models. Consequently, versatile in vitro tumor models ranging from simplistic two-dimensional (2D) cultures to three-dimensional (3D) cultures have been developed to mimic the microenvironments of the brain. In this dissertation, we developed that 1) characterization of tissue-derived extracellular matrix (tdECM), 2) reconstruction of patient brain tissue-derived extracellular matrix (pdECM)-based in vitro model, and 3) application of our in vitro 3D brain tumor model.
Advisors
Kim, Pilnamresearcher김필남researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 바이오및뇌공학과, 2019.2,[viii, 80 p. :]

Keywords

Microenvironment▼apatient brain tissue-derived extracellular matrix (pdECM)▼adecellularization▼a3-dimensional▼ahydrogel; 생체미세환경▼a조직유래 세포외기질▼a탈세포화▼a3차원▼a하이드로젤

URI
http://hdl.handle.net/10203/264678
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842473&flag=dissertation
Appears in Collection
BiS-Theses_Ph.D.(박사논문)
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