Characterization of Structural Variations in the Context of 3D Chromatin Structure

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dc.contributor.authorKim, Kyukwangko
dc.contributor.authorEom, Jung Hyunko
dc.contributor.authorJung, Inkyungko
dc.date.accessioned2019-08-22T02:20:24Z-
dc.date.available2019-08-22T02:20:24Z-
dc.date.created2019-08-19-
dc.date.created2019-08-19-
dc.date.created2019-08-19-
dc.date.created2019-08-19-
dc.date.issued2019-07-
dc.identifier.citationMOLECULES AND CELLS, v.42, no.7, pp.512 - 522-
dc.identifier.issn1016-8478-
dc.identifier.urihttp://hdl.handle.net/10203/264389-
dc.description.abstractChromosomes located in the nucleus form discrete units of genetic material composed of DNA and protein complexes. The genetic information is encoded in linear DNA sequences, but its interpretation requires an understanding of three-dimensional (3D) structure of the chromosome, in which distant DNA sequences can be juxtaposed by highly condensed chromatin packing in the space of nucleus to precisely control gene expression. Recent technological innovations in exploring higher-order chromatin structure have uncovered organizational principles of the 3D genome and its various biological implications. Very recently, it has been reported that large-scale genomic variations may disrupt higher-order chromatin organization and as a consequence, greatly contribute to disease-specific gene regulation for a range of human diseases. Here, we review recent developments in studying the effect of structural variation in gene regulation, and the detection and the interpretation of structural variations in the context of 3D chromatin structure.-
dc.languageEnglish-
dc.publisherKOREAN SOC MOLECULAR & CELLULAR BIOLOGY-
dc.titleCharacterization of Structural Variations in the Context of 3D Chromatin Structure-
dc.typeArticle-
dc.identifier.wosid000477946600002-
dc.identifier.scopusid2-s2.0-85070792556-
dc.type.rimsART-
dc.citation.volume42-
dc.citation.issue7-
dc.citation.beginningpage512-
dc.citation.endingpage522-
dc.citation.publicationnameMOLECULES AND CELLS-
dc.identifier.doi10.14348/molcells.2019.0137-
dc.identifier.kciidART002489826-
dc.contributor.localauthorJung, Inkyung-
dc.description.isOpenAccessY-
dc.type.journalArticleReview-
dc.subject.keywordAuthor3D chromatin structure-
dc.subject.keywordAuthorgene regulation-
dc.subject.keywordAuthorHi-C-
dc.subject.keywordAuthorstructural variation-
dc.subject.keywordAuthortopologically associating domain-
dc.subject.keywordPlusGENOMIC REARRANGEMENT-
dc.subject.keywordPlusX-CHROMOSOME-
dc.subject.keywordPlusTRANSCRIPTION FACTORS-
dc.subject.keywordPlusDOMAINS-
dc.subject.keywordPlusCONFORMATION-
dc.subject.keywordPlusORGANIZATION-
dc.subject.keywordPlusARCHITECTURE-
dc.subject.keywordPlusTOPOLOGY-
dc.subject.keywordPlusDISRUPTION-
dc.subject.keywordPlusACTIVATION-
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