DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Eunsook | ko |
dc.contributor.author | Lee, Jeehee | ko |
dc.contributor.author | Huh, Kang Moo | ko |
dc.contributor.author | Lee, Soo Hyeon | ko |
dc.contributor.author | Lee, Haeshin | ko |
dc.date.accessioned | 2019-08-21T06:20:11Z | - |
dc.date.available | 2019-08-21T06:20:11Z | - |
dc.date.created | 2019-08-19 | - |
dc.date.created | 2019-08-19 | - |
dc.date.created | 2019-08-19 | - |
dc.date.created | 2019-08-19 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.citation | ADVANCED HEALTHCARE MATERIALS, v.8, no.14 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.uri | http://hdl.handle.net/10203/264348 | - |
dc.description.abstract | Chitosan-catechol, inspired from mussel-adhesive-proteins, is characterized by the formation of an adhesive membrane complex through instant bonding with serum proteins not found in chitosan. Using this intrinsic property, chitosan-catechol is widely applied for hemostatic needles, general hemostatic materials, nanoparticle composites, and 3D printing. Despite its versatility, the practical use of chitosan-catechol in the clinic is limited due to its undesired immune responses. Herein, a catechol-conjugated glycol chitosan is proposed as an alternative hemostatic hydrogel with negligible immune responses enabling the replacement of chitosan-catechol. Comparative cellular toxicity and in vivo skin irritation between chitosan-catechol and glycol chitosan-catechol are evaluated. Their immune responses are also assessed using histological analysis after subcutaneous implantation into mice. The results show that glycol chitosan-catechol significantly attenuates the immune response compared with chitosan-catechol; this finding is likely due to the antibiofouling effect of ethylene glycol groups and the reduced adhesion of immune cells. Finally, the tissue adhesion and hemostatic ability of glycol chitosan-catechol hydrogels reveal that these ethylene glycol groups do not dramatically modify the adhesiveness and hemostatic ability compared with nonglycol chitosan-catechol. This study suggests that glycol chitosan-catechol can be a promising alternative to chitosan-catechol in various biomedical fields such as hemostatic agents. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.title | Toxicity-Attenuated Glycol Chitosan Adhesive Inspired by Mussel Adhesion Mechanisms | - |
dc.type | Article | - |
dc.identifier.wosid | 000477042600008 | - |
dc.identifier.scopusid | 2-s2.0-85065963115 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.issue | 14 | - |
dc.citation.publicationname | ADVANCED HEALTHCARE MATERIALS | - |
dc.identifier.doi | 10.1002/adhm.201900275 | - |
dc.contributor.localauthor | Lee, Haeshin | - |
dc.contributor.nonIdAuthor | Huh, Kang Moo | - |
dc.contributor.nonIdAuthor | Lee, Soo Hyeon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | chitosan | - |
dc.subject.keywordAuthor | glycol chitosan | - |
dc.subject.keywordAuthor | hemostasis | - |
dc.subject.keywordAuthor | hydrogels | - |
dc.subject.keywordAuthor | immunotoxicity | - |
dc.subject.keywordPlus | ANTIFOULING ORGANOSILANE ADLAYERS | - |
dc.subject.keywordPlus | LOW-MOLECULAR-WEIGHT | - |
dc.subject.keywordPlus | SURFACE-CHEMISTRY | - |
dc.subject.keywordPlus | TRANSFECTION EFFICIENCY | - |
dc.subject.keywordPlus | SOLUBLE CHITOSAN | - |
dc.subject.keywordPlus | ETHYLENE-GLYCOL | - |
dc.subject.keywordPlus | CATECHOL | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
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